AGH-192
Jump to navigation
Jump to search
![]() | |
Identifiers | |
---|---|
| |
PubChem CID | |
Chemical and physical data | |
Formula | C13H11FIN3 |
Molar mass | 355.155 g·mol−1 |
3D model (JSmol) | |
| |
|
AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full agonist at the 5HT7 serotonin receptor, derived from the older drug AGH-107. In animal tests it showed activity indicative of potential application in the treatment of neuropathic pain.[1]
See also
References
- ^ Hogendorf AS, Hogendorf A, Popiolek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ (2019). "Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers". European Journal of Medicinal Chemistry. 170: 261–275. doi:10.1016/j.ejmech.2019.03.017. PMID 30904783. S2CID 85498356.
Categories:
- Articles with short description
- Short description matches Wikidata
- Chemical articles without CAS registry number
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Serotonin receptor agonists
- Indoles
- Fluoroarenes
- Iodoarenes
- Imidazoles