AGH-107
Jump to navigation
Jump to search
 | |
| Identifiers | |
|---|---|
| |
| PubChem CID | |
| Chemical and physical data | |
| Formula | C13H12IN3 |
| Molar mass | 337.164 g·mol−1 |
| 3D model (JSmol) | |
| |
AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5HT7 serotonin receptor.[1] AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the related central nervous system targets. AGH-107 was found to reverse the impairment in novel object recognition caused by MK-801 in mice. The relatively short half-life in rodents inhibited its use as a molecular probe.
See also
References
- ^ Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, et al. (May 2017). "7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol". Scientific Reports. 7 (1): 1444. doi:10.1038/s41598-017-00822-4. PMC 5431432. PMID 28473721.
Categories:
- Articles with short description
- Short description matches Wikidata
- Chemical articles without CAS registry number
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Serotonin receptor agonists
- Indoles
- Iodoarenes
- Imidazoles