Zonadhesin

ZAN
Identifiers
Aliases	ZAN, zonadhesin (gene/pseudogene), zonadhesin
External IDs	OMIM: 602372 MGI: 106656 HomoloGene: 124417 GeneCards: ZAN
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,733,595 bp End 100,797,797 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 G2|5 76.4 cM Start 137,378,637 bp End 137,477,064 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver Top expressed in entorhinal cortex spermatid left colon embryo seminiferous tubule morula blastocyst jejunum spermatocyte stomach More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 7455 22635 Ensembl ENSG00000146839 ENSMUSG00000079173 UniProt Q9Y493 O88799 RefSeq (mRNA) NM_003386 NM_173055 NM_173056 NM_173057 NM_173058 NM_173059 NM_011741 RefSeq (protein) NP_003377 NP_775082 n/a Location (UCSC) Chr 7: 100.73 – 100.8 Mb Chr 5: 137.38 – 137.48 Mb PubMed search
Wikidata
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Zonadhesin is a protein that in humans is encoded by the ZAN gene.

Function

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition.

An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015].

Further reading

• Gasper J, Swanson WJ (November 2006). "Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution". Am. J. Hum. Genet. 79 (5): 820–30. doi:10.1086/508473. PMC 1698559. PMID 17033959.
• Gnanasekar M, Suleman FG, Ramaswamy K, Caldwell JD (October 2009). "Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening". Int. J. Mol. Med. 24 (4): 421–6. doi:10.3892/ijmm_00000248. PMID 19724880.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.