ZFAT-AS1
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In molecular biology, ZFAT antisense RNA 1 (non-protein coding), also known as ZFAT-AS1, is a long non-coding RNA. In peripheral blood lymphocytes, it is expressed in CD19+ B-cells.[1] It is an antisense transcript of the ZFAT gene, and negatively regulates the expression of a truncated form of ZFAT, TR-ZFAT, but not of ZFAT.[1] A single nucleotide polymorphism (SNP) which is located in the 3'-UTR of TR-ZFAT and the promoter region of ZFAT-AS1 regulates the expression of ZFAT-AS1, and therefore also affects expression of TR-ZFAT. This SNP is associated with an increased risk of autoimmune thyroid disease.[1]
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References
- ^ a b c Shirasawa S, Harada H, Furugaki K, Akamizu T, Ishikawa N, Ito K, et al. (2004). "SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease". Hum Mol Genet. 13 (19): 2221–31. doi:10.1093/hmg/ddh245. PMID 15294872.