YAF2

YAF2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2D9G
Identifiers
Aliases	YAF2, YY1 associated factor 2
External IDs	OMIM: 607534 HomoloGene: 136401 GeneCards: YAF2
Gene location (Human) Chr. Chromosome 12 (human) Band 12q12 Start 42,157,104 bp End 42,238,349 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle left ventricle sural nerve ganglionic eminence stromal cell of endometrium left lobe of thyroid gland monocyte prefrontal cortex right lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding transcription coactivator activity transcription corepressor activity Cellular component nucleus cytosol nucleoplasm Biological process positive regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10138 n/a Ensembl ENSG00000015153 n/a UniProt Q8IY57 n/a RefSeq (mRNA) NM_001012424 NM_001190977 NM_001190979 NM_001190980 NM_005748 NM_001320080 n/a RefSeq (protein) NP_001177906 NP_001177908 NP_001177909 NP_001307009 NP_005739 n/a Location (UCSC) Chr 12: 42.16 – 42.24 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mädge B, Geisen C, Möröy T, Schwab M (2003). "Yaf2 inhibits Myc biological function". Cancer Lett. 193 (2): 171–6. doi:10.1016/S0304-3835(02)00696-1. PMID 12706874.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode:2002Sci...296.1132O. doi:10.1126/science.1069861. PMID 12004135. S2CID 34863978.
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
• Bannasch D, Mädge B, Schwab M (2001). "Functional interaction of Yaf2 with the central region of MycN". Oncogene. 20 (41): 5913–9. doi:10.1038/sj.onc.1204747. PMID 11593398. S2CID 33486505.

External links

• YAF2 human gene location in the UCSC Genome Browser.
• YAF2 human gene details in the UCSC Genome Browser.