VSIG1

VSIG1
Identifiers
Aliases	VSIG1, 1700062D20Rik, GPA34, dJ889N15.1, V-set and immunoglobulin domain containing 1
External IDs	OMIM: 300620 MGI: 1926039 HomoloGene: 12703 GeneCards: VSIG1
Gene location (Human)
Chr.	X chromosome (human)
End	108,079,184 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	139,840,221 bp
RNA expression pattern
	Top expressed in
	pylorus; ; pancreatic epithelial cell; ; body of stomach; ; cardia; ; pancreatic ductal cell; ; gallbladder; ; gastric mucosa; ; fundus; ; blood; ; anterior pituitary;
	Top expressed in
	testicle; ; stomach; ; spermatid; ; spermatocyte; ; duodenum; ; islet of Langerhans; ; colon; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Orthologs
	340547
	78789
	ENSG00000101842
	ENSMUSG00000031430
	Q86XK7
	Q9D2J4
	NM_001170553; NM_182607
	NM_026103; NM_030181; NM_001359143
	NP_001164024; NP_872413
	NP_080379; NP_084457; NP_001346072
	Wikidata
View/Edit Human	View/Edit Mouse

V-set and immunoglobulin domain containing 1 is a protein that in humans is encoded by the VSIG1 gene.^[5]

Function

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in a normal stomach and testis, as well as in gastric, esophageal, and ovarian cancers. Alternatively spliced transcript variants, encoding different isoforms, have been found for this gene. [provided by RefSeq, Dec 2009].

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101842 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031430 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: V-set and immunoglobulin domain containing 1". Retrieved 2018-09-09.

Scanlan MJ, Ritter G, Yin BW, Williams C, Cohen LS, Coplan KA, Fortunato SR, Frosina D, Lee SY, Murray AE, Chua R, Filonenko VV, Sato E, Old LJ, Jungbluth AA (January 2006). "Glycoprotein A34, a novel target for antibody-based cancer immunotherapy". Cancer Immun. 6: 2. PMID 16405301.
Chen Y, Pan K, Li S, Xia J, Wang W, Chen J, Zhao J, Lü L, Wang D, Pan Q, Wang Q, Li Y, He J, Li Q (September 2012). "Decreased expression of V-set and immunoglobulin domain containing 1 (VSIG1) is associated with poor prognosis in primary gastric cancer" (PDF). J Surg Oncol. 106 (3): 286–93. doi:10.1002/jso.22150. hdl:2027.42/92382. PMID 22095633. S2CID 12675519.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.