User talk:Immcarle5

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Welcome!

Hello, Immcarle5, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 18:28, 12 January 2016 (UTC)[reply]

My Finalized Article to Edit

Isotype (immunology) 

     - This is one of the Wikipedia stubs that was listed on the page. I also wanted to do this page because I wanted to focus on the general explanation of isotype protein translation. It can also lead to more connections with the different immunoglobulin pages, so I won't run out of things to edit.

Bibliography 

    - Stavnezer, J., Immunoglobulin class switching, http://www.sciencedirect.com/science/article/pii/S0952791596800586; doi:10.1016/S0952-7915(96)80058-6
    - Tong, P., Wesemann D.R.,  Molecular Mechanisms of IgE Class Switch Recombination, http://link.springer.com/chapter/10.1007%2F978-3-319-13725-4_2; doi: 10.1007/978-3-319-13725-4_2
    - Panda, S., Ding, J., Natural Antibodies Bridge Innate and Adaptive Immunity, http://www.jimmunol.org/content/194/1/13.long, doi: 10.4049/​jimmunol.1400844
    - Xu, Y., et al., No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory, http://www.nature.com/cr/journal/v24/n6/full/cr201465a.html

Reference errors on 20 January

Hello, I'm ReferenceBot. I have automatically detected that an edit performed by you may have introduced errors in referencing. It is as follows:

Please check this page and fix the errors highlighted. If you think this is a false positive, you can report it to my operator. Thanks, ReferenceBot (talk) 00:20, 21 January 2016 (UTC)[reply]

Peer Review Comments

-Good lead section! It helps place what isotypes are in context. A few small ideas:

  • Add a link to the antibody Wikipedia page in first paragraph, or a sentence explaining what an antibody is. I think this would be relevant because isotypes in immunology really refer to the antibody isotypes.
  • Consider adding a sentence in the lead section, second paragraph about why isotypes are important. Perhaps something that would introduce class switching and how it helps us fight diverse infections? This give a little more context to a casual reader who does not know why they should care that antibodies have such diverse structure
  • Just an idea, you could also consider adding where each isotype works in the body during an immune response. Might help the audience better see that the varied classes all play different roles

-The first paragraph of “Class Switching” is awkwardly worded and does not help the reader fully understand why light chain rearrangement is important or necessary.

  • Consider adding general information about where light chain rearrangement takes place, what exactly happens to switch out the light chain (i.e. think in broad terms—enzymes in the bone marrow lead to a variety of changes in the DNA that encodes the light chain. This rearrangement creates diverse light chains, etc)
  • The word choice is not quite right for this section because it just happens, the cell doesn’t “choose”
  • References for first paragraph needed

-There are some redundant sentences in the second paragraph of “Class Switching” section. Read through again -I am not sure that the last four sentences of the article are completely accurate. Additionally, some of the information (like AID, cytokines, localization of Ab, DNA recombination) is mentioned but not explained. Try explaining in context so a non-immunology person could follow. Some facts to check and things to think about below:

  • The daughter B cell does not perform DNA recombination (happens in the mature naïve cell before becoming a plasma cell)
  • Some of the facts are thrown in with little explanation. Try adding some connecting sentences to contextualize rearrangement and how it leads to a better immune response
  • After rearrangement cells still can express IgM or IgD! Check your sources
  • Fix some word choice. The daughter B cells don’t really “select” their own heavy chain; it is determined by cytokine signaling opening up specific switch regions
  • The last sentence contradicts the second to last sentence

-Overall, your article has good bones, but it needs some cleaning up and clarification. Some of the sentences are disjointed from one another, and might be hard to follow for a casual reader because pieces of information are introduced without being explained or put in context. Especially focus on cleaning up the second paragraph of the “Class Switching” section to make it more cohesive, readable, and accurate. -It looks like you have added three good paragraphs to the article. I know Debby wanted 3-5, just something to think about! You have added five sources, so good job on that front! — Preceding unsigned comment added by Schaffm (talk • contribs) 18:30, 24 February 2016 (UTC)[reply]

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