The Petasis reaction can be viewed as a boronic acid equivalent of the Mannich reaction, and is often used as an alternative to the reductive amination reaction.
Applications
In one application the Petasis reaction is used for quick access to a multifunctional scaffold for divergent synthesis.[4][5]
^Petasis, N. A.; Akritopoulou, I. (1993). "The boronic acid mannich reaction: A new method for the synthesis of geometrically pure allylamines". Tetrahedron Lett.34: 583–586. doi:10.1016/S0040-4039(00)61625-8.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Petasis, N. A.; Zavialov, I. A. (1997). "A New and Practical Synthesis of -Amino Acids from Alkenyl Boronic Acids". J. Am. Chem. Soc.119: 445–446. doi:10.1021/ja963178n.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Petasis, N. A.; Zavialov, I. A. (1998). "Highly Stereocontrolled One-Step Synthesis of anti-β-Amino Alcohols from Organoboronic Acids, Amines, and α-Hydroxy Aldehydes". J. Am. Chem. Soc.120: 11798–11799. doi:10.1021/ja981075u. {{cite journal}}: Cite has empty unknown parameter: |1= (help)CS1 maint: multiple names: authors list (link)
^Naoya Kumagai, Giovanni Muncipinto, Stuart L. Schreiber (2006). "Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions". Angewandte Chemie International Edition. 45: 3635–3638. doi:10.1002/anie.200600497.{{cite journal}}: CS1 maint: multiple names: authors list (link)
