User:KrystalMarquis/P11 Protein Project Proposal
Introduction: The topic has been split up into sections to ensure that all aspects of the topic are thoroughly investigated. The divisions have been as follows:
History (focusing on who discovered the protein/when/how/etc…) and the biosynthesis relating to p11 protein will be covered by Falen Demsas.
The description of the protein and the drugs used to target the protein’s production will be examined by Kristaq Koci.
The structure, function, mechanism (what it does and how) will be explored by Krystal Marquis.
Finally Katherine Mohen will cover the pathology, focusing specifically on depression, and other associated disorders.
Detailed Description of Sections:
Give background of Nobelist Paul Greengard and his researchers in the discovery of the p11 protein, specifically describing the experiment he conducted on lab mice and how the lack of the p11 protein correlated with depression-like behavior. Also, how the protein is synthesized in normal subjects versus those who are suffering some form of depression will be investigated and discussed.
Describe how p11 levels are regulated by various factors including drugs, like dexamethosone, nitric oxide, transcription factors like activator protein-1, SP-1, and nuclear factor-kB, nerve growth factor, and other relevant factors that could be used to modulate P11 levels.
The structure and function of the p11 protein will be discussed as they relate to the production and the regulation of the protein. The interactions of p11 with other molecules, such as 5HT will be addressed, as well as its role in regulating mood and patient predisposition to depression.
Seratonin’s role in mood regulation renders Protein P11 a protein intimately associated with mood disorders, most significantly clinical depression and anxiety. Other disorders which may have link’s to P11’s interactions with 5-HT include Schizophrenia, ADD, ADHD, Bipolar Disorder, and Alzheimer’s disease.
Project Goal: The current article found on Wikipedia gives a brief description of the protein. It is lacking in scientific research, information, and citations. Through research we aim to make such findings available to the Wikipedia community.
References / External Links
http://www.jneurosci.org/cgi/content/full/29/6/1937 http://biopsychiatry.com/serotonin/p11.html
http://www.rockefeller.edu/research/abstract.php?id=53
http://clinicaltrials.gov/ct2/show/NCT00697268
http://www.npr.org/templates/story/story.php?storyId=5133423&ft=1&f=1007