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Deoxycytidine kinase (dCK) predominantly phosphorylates deoxycytidine (dC) and converts dC into deoxycytidine monophosphate. dCK catalyzes one of the initial steps in the nucleotide salvage pathway[1] and has the potential to phosphorylate other preformed nucleosides, specifically deoxyadenosine (dA) and deoxyguanosine (dG), and convert them into their monophosphate forms.[2] [3][4][5][6]

Therapeutics and Prodrugs

gemcitabine [7]

References

  1. ^ Nathanson, David A.; Armijo, Amanda L.; Tom, Michelle; Li, Zheng; Dimitrova, Elizabeth; Austin, Wayne R.; Nomme, Julian; Campbell, Dean O.; Ta, Lisa (2014-03-10). "Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication". The Journal of Experimental Medicine. 211 (3): 473–486. doi:10.1084/jem.20131738. ISSN 0022-1007. PMC 3949575. PMID 24567448.
  2. ^ Sabini, Elisabetta; Ort, Stephan; Monnerjahn, Christian; Konrad, Manfred; Lavie, Arnon (2003-07-01). "Structure of human dCK suggests strategies to improve anticancer and antiviral therapy". Nature Structural & Molecular Biology. 10 (7): 513–519. doi:10.1038/nsb942. ISSN 1072-8368.
  3. ^ Hazra, Saugata; Szewczak, Andrzej; Ort, Stephan; Konrad, Manfred; Lavie, Arnon (2011-04-12). "Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release". Biochemistry. 50 (14): 2870–2880. doi:10.1021/bi2001032. ISSN 1520-4995. PMC 3071448. PMID 21351740.
  4. ^ van der Wilt, C.L; Kroep, J.R; Loves, W.J.P; Rots, M.G; Groeningen, C.J Van; Kaspers, G.J; Peters, G.J. "Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver". European Journal of Cancer. 39 (5): 691–697. doi:10.1016/s0959-8049(02)00813-4.
  5. ^ Arnér, Elias S. J.; Eriksson, Staffan (1995-01-01). "Mammalian deoxyribonucleoside kinases". Pharmacology & Therapeutics. 67 (2): 155–186. doi:10.1016/0163-7258(95)00015-9.
  6. ^ Yamada, Yasukazu; Goto, Haruko; Ogasawara, Nobuaki (1983-11-22). "Purine nucleoside kinases in human T- and B-lymphoblasts". Biochimica et Biophysica Acta (BBA) - General Subjects. 761 (1): 34–40. doi:10.1016/0304-4165(83)90359-8.
  7. ^ "FDA Approval for Gemcitabine Hydrochloride". National Cancer Institute. Retrieved 2016-11-01.
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