User:AmberRenea/sandbox

Article Draft

Lead Paragraph (made some changes to the order of the paragraph and also added some of the information I figured out)

Helicobacter pylori, previously Campylobacter pylori, is a extracellular, gram-negative, microaerophilic bacterium commonly found in the stomach. H.pylori, characteristically has a helical shape, (from which the genus name derives) which is thought to have evolved to penetrate the mucoid lining of the stomach. In 1982, it was discovered by Austrian scientists Dr. Barry Marshall and Dr. Robin Warren. who found that it was present in a person with chronic gastritis and gastric ulcers. These conditions were not linked to a microbial cause due to the conventional thinking that no bacterium could survive in a humans stomach because of the pH level.

More than 50% of the world's population harbors H.Pylori in their upper gastrointestinal tract. However, over 80& of the individuals infected with the bacterium are asymptomatic. Infection is more prevalent in developing countries, and incidence is decreasing in western countries.

Genome (incorporate these sentences)

Studying the genome of Helicobacter pylori will allow a deeper understanding of its pathogenesis. According to Casteneda et. al, it was the "first bacterial species for which the whole genome sequence of two independent strains were available. The genome of strain "26695" consists of approximately 1.7 million base pairs, with some 1,576 genes. In comparison to the other strain "J99", their genomes showed about a 7% difference. Most genes that were absent between the two strains were considered strain-specific genes, ones that code for outer membrane proteins and other enzymes.

History

-Both Jaworski and Bizzozero are credited for the first description of H.pylori.

-In 1994 the National Institute of Health published a paper recognizing H.pylori as a cause of duodenal ulcers.

Symptoms

-acute = neutrophilic infiltration

-chronic = affects lymphocytes, plasma cells, macrophages

Evolution

Spelling error - Colonisation to Colonization

Article Critique

• Large focus on the history and pathophysiology of H.pylori
• The Genome and microscopy sections are smaller than the rest.
• Links to sources seem to be working and sources are fairly recent ranging from 2000-present
• Most sources from review articles
• No viewpoints; focused mostly on factual information.