USP52

PAN2
Identifiers
Aliases	PAN2, USP52, PAN2 poly(A) specific ribonuclease subunit, poly(A) specific ribonuclease subunit PAN2
External IDs	OMIM: 617447 MGI: 1918984 HomoloGene: 5918 GeneCards: PAN2
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3 Start 56,316,223 bp End 56,334,053 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 128,139,204 bp End 128,157,227 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right uterine tube anterior pituitary body of pancreas right lobe of liver tibial nerve canal of the cervix gastric mucosa right adrenal gland Top expressed in secondary oocyte hair follicle endocardial cushion conjunctival fornix medullary collecting duct renal corpuscle spermatocyte primitive streak thymus ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity nuclease activity exonuclease activity 3'-5'-exoribonuclease activity protein binding hydrolase activity nucleic acid binding metal ion binding Cellular component cytoplasm PAN complex cytosol P-body nucleus Biological process nuclear-transcribed mRNA poly(A) tail shortening mRNA processing nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of cytoplasmic mRNA processing body assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9924 103135 Ensembl ENSG00000135473 ENSMUSG00000005682 UniProt Q504Q3 Q8BGF7 RefSeq (mRNA) NM_014871 NM_001127460 NM_001166279 NM_001252326 NM_001252327 NM_133992 NM_001358822 RefSeq (protein) NP_001120932 NP_001159751 NP_055686 NP_001239255 NP_001239256 NP_598753 NP_001345751 Location (UCSC) Chr 12: 56.32 – 56.33 Mb Chr 10: 128.14 – 128.16 Mb PubMed search
Wikidata
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PAB-dependent poly(A)-specific ribonuclease subunit 2 is an enzyme that in humans is encoded by the PAN2 gene.

Further reading

• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (April 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, Garabaya C, Cal S, López-Otín C (January 2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochemical and Biophysical Research Communications. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Yamashita A, Chang TC, Yamashita Y, Zhu W, Zhong Z, Chen CY, Shyu AB (December 2005). "Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover". Nature Structural & Molecular Biology. 12 (12): 1054–63. doi:10.1038/nsmb1016. PMID 16284618. S2CID 19485927.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.