ULK2
| unc-51-like kinase 2 (C. elegans) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ULK2 | ||||||
| NCBI gene | 9706 | ||||||
| HGNC | 13480 | ||||||
| OMIM | 608650 | ||||||
| RefSeq | NM_014683 | ||||||
| UniProt | Q8IYT8 | ||||||
| Other data | |||||||
| EC number | 2.7.11.1 | ||||||
| Locus | Chr. 17 p11.2 | ||||||
| |||||||
Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.[1] The gene is located within the Smith–Magenis syndrome region on chromosome 17.
Structure and function
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.[2] ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.[3]
References
- ^ Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene. 18 (43): 5850–9. doi:10.1038/sj.onc.1202988. PMID 10557072.
- ^ "Entrez Gene: ULK2".
- ^ Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. doi:10.1101/gad.1151204. PMC 374236. PMID 15014045.
External links
- ULK2+protein,+mouse at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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