Template:Risk of breast cancer with menopausal hormone therapy by duration in large observational studies
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Study | Therapy | Hazard ratio (95% CI) |
---|---|---|
E3N-EPIC: Fournier et al. (2005)a | Transdermal estrogen plus progesterone <2 years 2–4 years ≥4 years |
0.9 (0.6–1.4) 0.7 (0.4–1.2) 1.2 (0.7–2.0) |
Transdermal estrogen plus progestin <2 years 2–4 years ≥4 years |
1.6 (1.3–2.0) 1.4 (1.0–1.8) 1.2 (0.8–1.7) | |
Oral estrogen plus progestin <2 years 2–4 years ≥4 years |
1.2 (0.9–1.8) 1.6 (1.1–2.3) 1.9 (1.2–3.2) | |
E3N-EPIC: Fournier et al. (2008) | Estrogen plus progesterone <2 years 2–4 years 4–6 years ≥6 years |
0.71 (0.44–1.14) 0.95 (0.67–1.36) 1.26 (0.87–1.82) 1.22 (0.89–1.67) |
Estrogen plus dydrogesterone <2 years 2–4 years 4–6 years ≥6 years |
0.84 (0.51–1.38) 1.16 (0.79–1.71) 1.28 (0.83–1.99) 1.32 (0.93–1.86) | |
Estrogen plus other progestogens <2 years 2–4 years 4–6 years ≥6 years |
1.36 (1.07–1.72) 1.59 (1.30–1.94) 1.79 (1.44–2.23) 1.95 (1.62–2.35) | |
E3N-EPIC: Fournier et al. (2014) | Estrogens plus progesterone or dydrogesterone <5 years ≥5 years |
1.13 (0.99–1.29) 1.31 (1.15–1.48) |
Estrogen plus other progestogens <5 years ≥5 years |
1.70 (1.50–1.91) 2.02 (1.81–2.26) | |
Footnotes: a = Oral estrogen plus progesterone was not analyzed because there was a low number of women who used this therapy. Sources: Main: [1] Additional: [2][3][4] |

See also
- Template:Risk of breast cancer with menopausal hormone therapy in large observational studies
- Template:Health risks in the conjugated estrogens and medroxyprogesterone acetate substudy of the Women's Health Initiative
References
- ↑ Mirkin S (August 2018). "Evidence on the use of progesterone in menopausal hormone therapy". Climacteric. 21 (4): 346–354. doi:10.1080/13697137.2018.1455657. PMID 29630427.
- ↑ Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F (April 2005). "Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort". Int. J. Cancer. 114 (3): 448–54. doi:10.1002/ijc.20710. PMID 15551359.
- ↑ Fournier A, Berrino F, Clavel-Chapelon F (January 2008). "Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study". Breast Cancer Res. Treat. 107 (1): 103–11. doi:10.1007/s10549-007-9523-x. PMC 2211383. PMID 17333341.
- ↑ Fournier A, Mesrine S, Dossus L, Boutron-Ruault MC, Clavel-Chapelon F, Chabbert-Buffet N (June 2014). "Risk of breast cancer after stopping menopausal hormone therapy in the E3N cohort". Breast Cancer Res. Treat. 145 (2): 535–43. doi:10.1007/s10549-014-2934-6. PMC 5924370. PMID 24781971.