Template:Norethisterone metabolism mini

Metabolism of norethisterone and its prodrugs in humans

The metabolic pathways involved in the metabolism of norethisterone in humans. Norethisterone acetate, norethisterone enanthate, etynodiol, etynodiol diacetate, lynestrenol, noretynodrel, quingestanol, and quingestanol acetate are all prodrugs of norethisterone. Ethinylestradiol is an estrogenic metabolite of norethisterone formed by cytochrome P450 enzymes. The two isomers of dihydronorethisterone and the four isomers of tetrahydronorethisterone are formed by 5α- and 5β-reductases and 3α- and 3β-hydroxysteroid dehydrogenases and have diminished or absent activity. Norethisterone and its metabolites also undergo hydroxylation via cytochrome P450 enzymes and conjugation via glucuronidation and sulfation at available hydroxyl (–OH) groups. Sources:

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