Template:Methadone at opioid receptors, monoamine transporters, and the NMDA receptor

Methadone at opioid receptors, monoamine transporters, and the NMDA receptor

Compound	Affinities (Ki)						Ratios		Ref
	MOR	DOR	KOR	SERT	NET	NMDAR	MOR:DOR:KOR	SERT:NET
Methadone	1.7 nM	435 nM	405 nM	ND	ND	2,500–8,300 nM	1:256:238	ND
Dextromethadone	19.7 nM	960 nM	1,370 nM	992 nM	12,700 nM	2,600–7,400 nM	1:49:70	1:13
Levomethadone	0.945 nM	371 nM	1,860 nM	14.1 nM	702 nM	2,800–3,400 nM	1:393:1968	1:50
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