Talk:Vasomotor
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Nasal hyperreactivity in allergic rhinitis and idiopathic rhinitis correlated with strong innervation pattern with sensory nerve fibers containing SP and CGRP demonstrated neurogenic inflammation, when compared to normal controls.
HNO. 2008 Aug;56(8):799-807. [Ultrastructural changes in allergic rhinitis vs. idiopathic rhinitis]
[Article in German]
Knipping S, Holzhausen HJ, Riederer A, Schrom T.
Universitätsklinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Kopf - und Halschirurgie, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Strasse 12, 06097 Halle/Saale. stephan.knipping@medizin.uni-halle.de Abstract
BACKGROUND: Nasal hyperreactivity is one of the most important underlying mechanisms in allergic rhinitis (AR) as well as idiopathic rhinitis (IR). The aim of the present study was to examine pathomorphological changes in nasal mucosa in these subgroups of rhinitis.
PATIENTS AND METHODS: Tissue samples of human inferior turbinates from 20 patients with AR and 16 patients with IR were taken during nasal surgery and preserved in glutaraldehyde or paraformaldehyde. Ultrathin sections of specimens from 15 patients without chronic inflammation of nasal mucosa were used as controls. Primary antibodies against substance P (SP), calcitonin-gene-related peptide (CGRP), and endothelial nitric oxide synthase (NOS III) were applied, and the immunocomplexes were visualized by an immunocytochemical staining technique using gold-labeled antibodies. Immunostained structures were photodocumented using light and transmission electron microscopy.
RESULTS: The nasal mucosa of patients with AR and IR showed similarities on the ultrastructural level. A strong innervation pattern with sensory nerve fibers containing SP and CGRP demonstrated neurogenic inflammation. Extensive edema and cellular infiltrations were found in AR. A decreased presence of eosinophils and nitric oxide was observed in IR.
CONCLUSIONS: On the ultrastructural level, AR and IR showed many similarities but also some differences. Based on these findings, anti-inflammatory therapy could be recommended for both types of rhinitis.
PMID 18651116—Preceding unsigned comment added by Ocdncntx (talk • contribs) 13:52, 17 November 2010 (UTC)
Why you added this to the vasomotor talk page? It seems that this material is unrelated to the vasomotor? Cerevisae (talk) 15:53, 17 November 2010 (UTC)