Talk:Hippuric acid

some data

other names N-Benzoylglycine Benzoylglycine Benzoylaminoacetic acid

CAS 495-69-2 179.18 g/mol melting point 188 - 191 Stone 13:34, 31 January 2006 (UTC)

Reference

Wilh. Keller (1842). "Ueber Verwandlung der Benzoësäure in Hippursäure". Annalen der Chemie und Pharmacie. 43 (1): 108–111. doi:10.1002/jlac.18420430106.--Stone 20:46, 22 July 2007 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Hippuric acid/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Not a terribly interesting metabolite, though glycination is a recognised detox pathway. As it's one of the major constituents of the human urinary organic acid profile, someone who's up to date or has access to literature search facilities could usefully expand the article a bit. Brethenshort (talk) 20:54, 12 January 2009 (UTC)

Last edited at 20:54, 12 January 2009 (UTC). Substituted at 17:57, 29 April 2016 (UTC)

A Biomarker for Parkinson's disease

I don't feel qualified to post the details of this but this compound has been identified as a biomarker (along with eicosane and octadecanal) in the sebum of people suffering from Parkinson's disease which may lead to a predictive test which could be used before symptoms manifest themselves.

I shall post similar talk topics in the three other relevant articles.

Stan staveley (talk) 14:25, 24 March 2019 (UTC)stan_staveley

References

Metabolism of phenols

The introduction to this article asserts that hippuric acid concentrations have been shown to increase with the consumption of "phenolic compounds" and lists sources of these compounds as fruits, teas etc. (aka natural products).

First of all, the source for this claim does not explain where this information comes from. In fact, the source seems to be a paragraph composed of texts from at least two different sources, the latter being about the oxidation of TOLUENE, not phenol (which would make more sense mechanistically).

Second of all, even if these phenolic compounds are metabolized to hippuric acid, it is likely not due to their identity as phenols. Instead, these natural phenolic compounds are usually phenolic acids, and should be labeled as such. Simple phenols will most likely not undergo this metabolism.

The introduction should either be edited to reflect this, or another source found. Npjl (talk) 22:39, 13 March 2024 (UTC)