Talk:Diprenorphine
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Diprenorphine for human opioid overdose
To bring this speculation further with sources, can anyone find bingind affinity and half-life for diprenorphine?--Custoo (talk) 09:36, 15 October 2014 (UTC)
Super-potent opioids
Article states These super-potent opioids, with the single exception of buprenorphine [...], are not used in humans because the dose for a human is so small that it would be difficult to measure properly. I find this explanation lacking in clarity, sources and seriousness. LD50 of Etorphine is listed as 30 μg, whereas LD50 of Botox is 2 ng/kg, so 200 ng for 100 kg human. Therefore the small amount of substance needed is not the issue. Therapeutic index of Botox is allegedly around 100:1. I could not find the therapeutic index of Etorphine, nor other "super opioids", but some have allegedly unfavourable therapeutic indices, whereas remifentanil (not the faintest, but still used with humans) has an index of 33 000:1. Indices seem independent of potency. There must be a different reason for not using "super opioids". --Waydot (talk) 19:50, 30 August 2018 (UTC)
I can't find any reference for hallucinatory effects of diprenorphine. I read all of the citations and one of them mentions it but provides no evidence or further citation. I've dug deep in pubmed and google scholar and have found nothing. This claim should be removed.
98.26.111.186 (talk) 04:18, 10 May 2019 (UTC)