Talk:Antigen-presenting cell

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Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 28 August 2018 and 21 December 2018. Further details are available on the course page. Student editor(s): Jessica.Kim285.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:25, 17 January 2022 (UTC)[reply]

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle6. Peer reviewers: Immcarle8.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 14:28, 16 January 2022 (UTC)[reply]

Untitled

Is there somebody that know, if there is rules for whis sequences are presented by APCs? If yes, can he describe it to page of Antigen-presenting cell? Thanks. Bal.


As well, there are specialized cells in particular organs (e.g., microglia in the brain, Kupffer cells in the liver), derived from macrophages that are also effective APCs.

I deleted this this because microglia, Kupffer cells, histocytes, osteoclasts, etc are just specific names for macrophages found in particular locations, and it is redundunt to mention them again. —Preceding unsigned comment added by 99.232.233.87 (talk) 18:02, 16 July 2008 (UTC)[reply]

This article really needs some sources for verification —Preceding unsigned comment added by 141.132.103.146 (talk) 00:52, 11 August 2010 (UTC)[reply]

Line about B cells as APC doesn't make sense

The line reads: "B-cells, which expresses (as B cell receptor) and secretes a specific antibody, can internalize the antigen which bind to its BCR and present it incorporated to MHC II molecule, but are inefficient APC for most other antigens."

This line never states what type of antigen the B is picking up, so it's conclusion that it is not an effective APC for most other antigens is confusing. Can anyone clarify this? —Preceding unsigned comment added by Mizower (talk • contribs) 01:43, 16 October 2010 (UTC)[reply]

Macrophage somewhat implied to be a T-cell?

This text, in a bullet within the Professional APCs section, is unclear:

Macrophages, which are also CD4+ cells and are therefore susceptible to infection by HIV as well, since HIV invades immune cells through CD4+ receptor interactions.

I'm studying this, and from what I've read elsewhere, macrophages aren't "CD4+ cells", but cells with exhibit the CD4 complex on their cell membrane. Since T-Helper cells are often referred to as "CD4+ T Helper cells" (e.g., in the introduction to CD4), the text as it stands can be read to imply that a macrophage is a type of T-cell. I'm not far enough along in my studies to want to correct this myself, however. — Preceding unsigned comment added by 71.198.248.252 (talk) 07:28, 17 October 2014 (UTC)[reply]

  • Antigen is internalized via endocytosis
  • Antigen is digested and destroyed in the phagolysosome
  • Antigen presenting cell(A.P.C):is cell that diplays foreign antigen complexed with Major histocompatibitity complexes (M.H.C) on their surfaces.08:34, 25 March 2015 (UTC)41.68.104.82 (talk)Cite error: There are <ref> tags on this page without content in them (see the help page).

Updating and adding new sections to the page

I've been assigned to work on this page. I'm planning to add a few new sections and lots of new information. This is my bibliography as it stands right now; any questions or comments are welcome. [1][2][3][4][5] [6][7][8][9]Immcarle6 (talk) 20:57, 2 February 2016 (UTC)[reply]

Here is a draft of a new lead section for this article. Comments and suggestions welcome: An antigen-presenting cell (APC) is a cell that displays antigen on its surface in order to interact with or activate immune cells. Professional antigen-presenting cells, including macrophages, B cells, and dendritic cells, use class II major histocompatibility complexes to perform this process, which is called antigen presentation. These cells internalize and process foreign antigen before displaying short peptides in MHC class II molecules. T helper cells can then interact with the peptide and MHC molecule using their T cell receptor (TCR). Only exogenous antigen can be displayed on MHC class II molecules.

Non-professional antigen presenting cells include almost all cell types in the body, and use an MHC class I molecule to display endogenous antigen on the cell membrane. These peptides originated within the cell itself, in contrast to the exogenous antigen displayed by professional APCs. Cytotoxic T cells are able to interact with endogenous antigen presented using an MHC class I molecule.

Antigen-presenting cells are vital for an effective adaptive immune response, as the functioning of both cytotoxic and helper T cells is dependent on APCs. Antigen presentation can contribute to immune responses against both intracellular and extracellular pathogens as well as defense against tumors. Some new therapies against cancer involve the creation of artificial APCs to prime the adaptive immune system to target malignant cells. Immcarle6 (talk) 01:38, 10 February 2016 (UTC)[reply]

Maturation versus Activation

I think that the illustration in the upper-left corner of this page is misleading. Maturation is the process that occurs in the thymus when thymocytes are exposed to APCs displaying self-antigens. Most thymocytes die (apoptose) as a result of this process, whereas the survivors "mature". Outside of the thymus, APCs displaying non-self antigens cause T-cells to become activated against the antigen, thereby resulting in destruction of the pathogen by the adaptive immune system. --Ben Best:Talk 14:04, 24 December 2019 (UTC)[reply]

References

  1. ^ Perica, Karlo; Kosmides, Alyssa K.; Schneck, Jonathan P. (2015-04-01). "Linking form to function: Biophysical aspects of artificial antigen presenting cell design". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. SI: Nanoscale Membrane Organisation. 1853 (4): 781–790. doi:10.1016/j.bbamcr.2014.09.001. PMC 4344884. PMID 25200637.
  2. ^ Eggermont, Loek J.; Paulis, Leonie E.; Tel, Jurjen; Figdor, Carl G. (2014-09-01). "Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells". Trends in Biotechnology. 32 (9): 456–465. doi:10.1016/j.tibtech.2014.06.007. ISSN 0167-7799. PMC 4154451. PMID 24998519.
  3. ^ Goyvaerts, Cleo; Breckpot, Karine (2015-10-25). "Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines". Journal of Immunology Research. 2015: 1–18. doi:10.1155/2015/785634. PMC 4637118. PMID 26583156.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Kambayashi, Taku; Laufer, Terri M. "Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?". Nature Reviews Immunology. 14 (11): 719–730. doi:10.1038/nri3754.
  5. ^ Grainger, John R.; Askenase, Michael H.; Guimont-Desrochers, Fanny; Fonseca, Denise Morais da; Belkaid, Yasmine (2014-05-01). "Contextual functions of antigen-presenting cells in the gastrointestinal tract". Immunological Reviews. 259 (1): 75–87. doi:10.1111/imr.12167. ISSN 1600-065X. PMC 3992430. PMID 24712460.
  6. ^ Mann, Elizabeth R. "Intestinal antigen-presenting cells in mucosal immune homeostasis: Crosstalk between dendritic cells, macrophages and B-cells". World Journal of Gastroenterology. 20 (29). doi:10.3748/wjg.v20.i29.9653. PMC 4123356. PMID 25110405.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  7. ^ den Haan, Joke M.M.; Arens, Ramon; Zelm, Menno C. van. "The activation of the adaptive immune system: Cross-talk between antigen-presenting cells, T cells and B cells". Immunology Letters. 162 (2): 103–112. doi:10.1016/j.imlet.2014.10.011.
  8. ^ Levin, Clement; Perrin, Helene; Combadiere, Behazine (2015-01-01). "Tailored immunity by skin antigen-presenting cells". Human Vaccines & Immunotherapeutics. 11 (1): 27–36. doi:10.4161/hv.34299. ISSN 2164-5515. PMC 4514408. PMID 25483512.
  9. ^ Zuidscherwoude, Malou; Winde, Charlotte M. de; Cambi, Alessandra; Spriel, Annemiek B. van (2014-02-01). "Microdomains in the membrane landscape shape antigen-presenting cell function". Journal of Leukocyte Biology. 95 (2): 251–263. doi:10.1189/jlb.0813440. ISSN 0741-5400. PMID 24168856.

Professional antigen-presenting cells

In the second paragraph of the lead we have a sentence beginning, "Professional antigen-presenting cells, including macrophages, B cells and dendritic cells, present foreign antigens to helper T cells,..."

Is the word "Professional" being used in a subject specific way here with which I am unfamiliar, or is it simply a poor choice of word? Hedles (talk) 17:03, 20 February 2021 (UTC)[reply]

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