TRIM29

TRIM29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CSV
Identifiers
Aliases	TRIM29, ATDC, tripartite motif containing 29
External IDs	OMIM: 610658 MGI: 1919419 HomoloGene: 8100 GeneCards: TRIM29
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 120,111,286 bp End 120,185,529 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.1 Start 43,222,145 bp End 43,247,412 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums skin of abdomen vulva human penis nipple oral cavity cervix epithelium body of tongue palpebral conjunctiva hair follicle Top expressed in lip esophagus epidermis skin of abdomen skin of back hair follicle conjunctival fornix cornea middle ear Eustachian tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity zinc ion binding p53 binding protein binding metal ion binding cadherin binding involved in cell-cell adhesion identical protein binding Cellular component intracellular anatomical structure cytoplasm lysosome Biological process negative regulation of protein localization to nucleus negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II cell-cell adhesion immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23650 72169 Ensembl ENSG00000137699 ENSMUSG00000032013 UniProt Q14134 Q8R2Q0 RefSeq (mRNA) NM_012101 NM_058193 NM_001330382 NM_023655 RefSeq (protein) NP_001317311 NP_036233 NP_076144 Location (UCSC) Chr 11: 120.11 – 120.19 Mb Chr 9: 43.22 – 43.25 Mb PubMed search
Wikidata
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Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene.

Function

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia–telangiectasia phenotype.

Interactions

TRIM29 has been shown to interact with TRIM23 and GCC1.

Further reading

• Kapp LN, Painter RB, Yu LC, van Loon N, Richard CW, James MR, Cox DR, Murnane JP (1992). "Cloning of a candidate gene for ataxia-telangiectasia group D". Am. J. Hum. Genet. 51 (1): 45–54. PMC 1682873. PMID 1609804.
• Hosoi Y, Kapp LN (1994). "Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues". Int. J. Radiat. Biol. 66 (6 Suppl): S71-6. doi:10.1080/09553009414551891. PMID 7530755.
• Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF (1995). "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7824–8. Bibcode:1995PNAS...92.7824B. doi:10.1073/pnas.92.17.7824. PMC 41238. PMID 7644499.
• Murnane JP, Zhu Y, Young BR, Christman MF (1994). "Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation". Int. J. Radiat. Biol. 66 (6 Suppl): S77-84. doi:10.1080/09553009414551901. PMID 7836856.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Leonhardt EA, Kapp LN, Young BR, Murnane JP (1994). "Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC)". Genomics. 19 (1): 130–6. doi:10.1006/geno.1994.1022. PMID 8188213.
• Richard CW, Cox DR, Kapp L, Murnane J, Cornelis F, Julier C, Lathrop GM, James MR (1993). "A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus". Genomics. 17 (1): 1–5. doi:10.1006/geno.1993.1275. PMID 8406440.
• Laderoute KR, Knapp AM, Green CJ, Sutherland RM, Kapp LN (1996). "Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells". Int. J. Cancer. 66 (6): 772–8. doi:10.1002/(SICI)1097-0215(19960611)66:6<772::AID-IJC11>3.0.CO;2-5. PMID 8647648. S2CID 29088136.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Tauchi H, Green C, Knapp M, Laderoute K, Kapp L (2000). "Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein". Mutagenesis. 15 (2): 105–8. doi:10.1093/mutage/15.2.105. PMID 10719033.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K (2006). "Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC". Biochem. Biophys. Res. Commun. 348 (2): 728–34. doi:10.1016/j.bbrc.2006.07.115. PMID 16890201.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.