TDBzcholine
Jump to navigation
Jump to search
Names | |
---|---|
IUPAC name
4-[(3-Trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine
| |
Identifiers | |
3D model (JSmol)
|
|
ChemSpider | |
PubChem CID
|
|
UNII | |
| |
| |
Properties | |
C14H17F3N3O2+1 | |
Molar mass | 316.304 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
TDBzcholine is a diazirine analog of acetylcholine that can be used to label the nicotinic acetylcholine receptor.
Mechanism of action
TDBzcholine is able to bind to the nicotinic acetylcholine receptor. Once TDBzcholine is bound to the receptor, TDBzcholine can be activated by exposing the sample to UV light. This led to formation of a highly reactive carbene radical that can react with amino acid residues in the receptor and become covalently bound to the receptor.[1]
See also
References
- ^ "Pharmacology of cell excitation". Biochemical Pharmacology Lecture Notes.
Categories:
- Articles with short description
- Short description is different from Wikidata
- Articles without InChI source
- Articles without EBI source
- Articles without KEGG source
- Articles containing unverified chemical infoboxes
- Chembox image size set
- Short description matches Wikidata
- Diazirines
- Choline esters
- Benzoate esters
- Trifluoromethyl compounds
- Nicotinic acetylcholine receptors
- All stub articles
- Pharmacology stubs