TAC4
Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.[3][4][5]
This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000176358 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ (Mar 2001). "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis". Nat Immunol. 1 (5): 392–7. doi:10.1038/80826. PMID 11062498. S2CID 24408728.
- ^ Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q (Oct 2002). "Identification, localization and receptor characterization of novel mammalian substance P-like peptides". Gene. 296 (1–2): 205–12. doi:10.1016/S0378-1119(02)00861-2. PMID 12383518.
- ^ a b "Entrez Gene: TAC4 tachykinin 4 (hemokinin)".
Further reading
- Page NM (2007). "Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides". Vascul. Pharmacol. 45 (4): 200–8. doi:10.1016/j.vph.2005.08.028. PMID 16931167.
- Page NM (2004). "Hemokinins and endokinins". Cell. Mol. Life Sci. 61 (13): 1652–63. doi:10.1007/s00018-004-4035-x. PMID 15224188. S2CID 31599641.
- Cunningham S, O'Doherty C, Patterson C, et al. (2007). "The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis" (PDF). J. Neuroimmunol. 183 (1–2): 208–13. doi:10.1016/j.jneuroim.2006.11.002. PMID 17175032. S2CID 23701000.
- Page NM, Bell NJ, Gardiner SM, et al. (2003). "Characterization of the endokinins: Human tachykinins with cardiovascular activity". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6245–50. Bibcode:2003PNAS..100.6245P. doi:10.1073/pnas.0931458100. PMC 156357. PMID 12716968.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bellucci F, Carini F, Catalani C, et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1". Br. J. Pharmacol. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMC 1573107. PMID 11786503.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
External links
- Overview of all the structural information available in the PDB for UniProt: Q86UU9 (Tachykinin-4) at the PDBe-KB.
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