Syntaphilin

SNPH
Identifiers
Aliases	SNPH, bA314N13.5, syntaphilin
External IDs	OMIM: 604942 MGI: 2139270 HomoloGene: 8817 GeneCards: SNPH
Gene location (Human) Chr. Chromosome 20 (human) Band 20p13 Start 1,266,280 bp End 1,309,328 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 G3 Start 151,590,549 bp End 151,632,593 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Region I of hippocampus proper Brodmann area 46 postcentral gyrus orbitofrontal cortex entorhinal cortex superior frontal gyrus inferior olivary nucleus cingulate gyrus dorsolateral prefrontal cortex amygdala Top expressed in visual cortex superior frontal gyrus subiculum hippocampus proper prefrontal cortex cingulate gyrus olfactory tubercle primary motor cortex cerebellar cortex Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function syntaxin-1 binding Cellular component cytoplasm integral component of membrane neuron projection cytoplasmic microtubule cell junction neuronal cell body plasma membrane synapse presynaptic membrane mitochondrial membranes membrane Biological process brain development synaptic vesicle docking neurotransmitter secretion neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9751 241727 Ensembl ENSG00000101298 ENSMUSG00000027457 UniProt O15079 Q80U23 RefSeq (mRNA) NM_014723 NM_001318234 NM_001291076 NM_001291077 NM_198214 RefSeq (protein) NP_001305163 NP_055538 NP_001278005 NP_001278006 NP_937857 Location (UCSC) Chr 20: 1.27 – 1.31 Mb Chr 2: 151.59 – 151.63 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Syntaphilin is a protein that in humans is encoded by the SNPH gene.

Function

Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Das S, Gerwin C, Sheng ZH (2003). "Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis". J. Biol. Chem. 278 (42): 41221–6. doi:10.1074/jbc.M304851200. PMID 12896979.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.