Streptomyces clavuligerus

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Streptomyces clavuligerus
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Actinomycetota
Class: Actinomycetia
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species:
S. clavuligerus
Binomial name
Streptomyces clavuligerus
Higgens & Kastner 1971

Streptomyces clavuligerus is a species of Gram-positive bacterium notable for producing clavulanic acid.[1]

S. clavuligerus ATCC 27064 (NRRL 3585, DSM 738) was first described by Higgens and Kastner (1971), who isolated it from a South American soil sample.[2] Its name refers to the shape of its spore-bearing hyphal branches: from the Latin clavula 'little club' and igerus 'bearing'. S. clavuligerus spores are gray to grayish-green.[2]

S. clavuligerus produces over 20 secondary metabolites, including many beta-lactam antibiotics such as clavulanic acid, cephamycin C, deacetoxycephalosporin C, penicillin N (an intermediate in cephamycin C pathway), and at least four other clavams.[3][4] Non-β-lactam antibiotics include holomycin and an antibiotic complex, MM 19290, related to tunicamycin;[5] a beta-lactamase-inhibitory protein (BLIP) has also been described.[6] For S. clavuligerus ATCC 27064, a teleocidin biosynthetic gene cluster was identified in early isolates held at ATCC, apparently missing from later isolates used for industrial production of clavulanic acid.[7]

Another important characteristic of S. clavuligerus is that it is not able to use glucose as a carbon source because it lacks a glucose transport system.[8][9]

It also possesses all the enzymes of the urea cycle, which is unusual for a prokaryote, although it is not clear whether the urea cycle is functional.[10]

References

  1. ^ Reading C, Cole M (1977). "Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus". Antimicrob Agents Chemother. 11 (5): 852–7. doi:10.1128/aac.11.5.852. PMC 352086. PMID 879738.
  2. ^ a b Higgens CE, Kastner RE (1971). "Streptomyces clavuligerus sp. nov., a beta-lactam antibiotic producer". International Journal of Systematic Bacteriology. 21 (4): 326–31. doi:10.1099/00207713-21-4-326.
  3. ^ Nabais AMA, Dafonseca MMR (1995). "The Effect of Solid Medium Composition on Growth and Sporulation of Streptomyces-Clavuligerus - Spore Viability During Storage at +4-Degrees-C". Biotechnology Techniques. 9 (5): 361–4. doi:10.1007/BF00638871.
  4. ^ Tahlan K, Anders C, Jensen S (2004). "The Paralogous Pairs of Genes Involved in Clavulanic Acid and Clavam Metabolite Biosynthesis Are Differently Regulated in Streptomyces clavuligerus". J Bacteriol. 186 (18): 6286–97. doi:10.1128/JB.186.18.6286-6297.2004. PMC 515150. PMID 15342599.
  5. ^ Baggaley K, Brown A, Schofield C (1997). "Chemistry and biosynthesis of clavulanic acid and other clavams". Nat Prod Rep. 14 (4): 309–33. doi:10.1039/np9971400309. PMID 9281835.
  6. ^ Doran J, Leskiw B, Aippersbach S, Jensen S (1990). "Isolation and characterization of a beta-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene". J Bacteriol. 172 (9): 4909–18. doi:10.1128/jb.172.9.4909-4918.1990. PMC 213145. PMID 2203736.
  7. ^ Pivk Lukančič, P; Drčar, T; Bruccoleri, R; Črnugelj, M; Mrak, P (February 2022). "Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064". Applied Microbiology and Biotechnology. 106 (4): 1521–1530. doi:10.1007/s00253-022-11805-5. PMC 8882083. PMID 35138454.
  8. ^ Aharonowitz Y, Demain A (1 August 1978). "Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus". Antimicrob Agents Chemother. 14 (2): 159–64. doi:10.1128/aac.14.2.159. PMC 352426. PMID 697343.
  9. ^ Garcia-Dominguez M, Martin J, Liras P (1989). "Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant". J Bacteriol. 171 (12): 6808–14. doi:10.1128/jb.171.12.6808-6814.1989. PMC 210580. PMID 2687256.
  10. ^ Kirk S (2000). "The physiology of clavulanic acid production by Streptomyces clavuligerus (PhD thesis)". University of Surrey, UK. {{cite journal}}: Cite journal requires |journal= (help)

Further reading

Alvarez-Alvarez, R.; Rodriguez-Garcia, A.; Santamarta, I.; Perez-Redondo, R.; Prieto-Dominguez, A.; Martinez-Burgo, Y.; Liras, Paloma (May 2014). "Transcriptomic analysis of Streptomyces clavuligerus Delta ccaR:: tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation". Microbial Biotechnology. 7 (3): 221–231. doi:10.1111/1751-7915.12109. PMC 3992018. PMID 24450885.

External links


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