Srp receptor alpha subunit

SRPRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FH5, 2GO5, 5L3Q
Identifiers
Aliases	SRPRA, DP, Sralpha, SRPR, SRP receptor alpha subunit, SRP receptor subunit alpha
External IDs	OMIM: 182180 MGI: 1914648 HomoloGene: 2364 GeneCards: SRPRA
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.2 Start 126,262,938 bp End 126,269,144 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A4 Start 35,111,471 bp End 35,159,269 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland body of pancreas anterior pituitary stromal cell of endometrium corpus epididymis body of stomach right lobe of liver minor salivary glands left uterine tube left lobe of thyroid gland Top expressed in parotid gland lacrimal gland submandibular gland triceps brachii muscle seminal vesicula extensor digitorum longus muscle sternocleidomastoid muscle plantaris muscle molar islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding signal recognition particle binding GTP binding GTPase activity RNA binding Cellular component signal recognition particle receptor complex integral component of membrane extracellular exosome endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process IRE1-mediated unfolded protein response intracellular protein transport cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane transport protein targeting protein targeting to ER Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6734 67398 Ensembl ENSG00000182934 ENSMUSG00000032042 UniProt P08240 Q9DBG7 RefSeq (mRNA) NM_003139 NM_001177842 NM_026130 RefSeq (protein) NP_001171313 NP_003130 NP_080406 Location (UCSC) Chr 11: 126.26 – 126.27 Mb Chr 9: 35.11 – 35.16 Mb PubMed search
Wikidata
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SRP receptor alpha subunit is a protein that in humans is encoded by the SRPRA gene.

Function

The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.