STK39

STK39
Identifiers
Aliases	STK39, DCHT, PASK, SPAK, serine/threonine kinase 39
External IDs	OMIM: 607648 MGI: 1858416 HomoloGene: 22739 GeneCards: STK39
Gene location (Human) Chr. Chromosome 2 (human) Band 2q24.3 Start 167,954,020 bp End 168,247,595 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C1.3 Start 68,040,789 bp End 68,302,612 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons parotid gland palpebral conjunctiva inferior ganglion of vagus nerve tibia subthalamic nucleus superior vestibular nucleus corpus callosum Brodmann area 23 Top expressed in spermatocyte spermatid seminiferous tubule salivary gland submandibular gland lacrimal gland parotid gland atrium facial motor nucleus anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein binding ATP binding protein serine/threonine kinase activity kinase activity protein kinase binding Cellular component membrane basolateral plasma membrane apical plasma membrane cytoskeleton nucleoplasm extrinsic component of membrane intracellular membrane-bounded organelle nucleus cytoplasm cytosol Biological process negative regulation of protein phosphorylation intracellular signal transduction signal transduction phosphorylation positive regulation of potassium ion transport cellular hypotonic response regulation of blood pressure negative regulation of potassium ion transmembrane transporter activity regulation of inflammatory response negative regulation of potassium ion transmembrane transport negative regulation of pancreatic juice secretion peptidyl-threonine phosphorylation positive regulation of ion transmembrane transporter activity maintenance of lens transparency negative regulation of creatine transmembrane transporter activity negative regulation of sodium ion transmembrane transporter activity regulation of mitotic cell cycle stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process protein phosphorylation peptidyl-serine phosphorylation protein autophosphorylation ion homeostasis positive regulation of T cell chemotaxis chemokine (C-X-C motif) ligand 12 signaling pathway cellular response to chemokine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27347 53416 Ensembl ENSG00000198648 ENSMUSG00000027030 UniProt Q9UEW8 Q9Z1W9 RefSeq (mRNA) NM_013233 NM_016866 RefSeq (protein) NP_037365 NP_058562 Location (UCSC) Chr 2: 167.95 – 168.25 Mb Chr 2: 68.04 – 68.3 Mb PubMed search
Wikidata
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STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Some studies suggest that this gene might be linked to high blood pressure.

Further reading

• Qi H, Labrie Y, Grenier J, et al. (2001). "Androgens induce expression of SPAK, an STE20/SPS1-related kinase, in LNCaP human prostate cancer cells". Mol. Cell. Endocrinol. 182 (2): 181–92. doi:10.1016/S0303-7207(01)00560-3. PMID 11514053. S2CID 26078681.
• Dowd BF, Forbush B (2003). "PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)". J. Biol. Chem. 278 (30): 27347–53. doi:10.1074/jbc.M301899200. PMID 12740379.
• Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na⁺-K⁺-2Cl⁻ cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". J. Biol. Chem. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
• Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMC 1479760. PMID 16669787.
• Polek TC, Talpaz M, Spivak-Kroizman TR (2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem. Biophys. Res. Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Yan Y, Nguyen H, Dalmasso G, et al. (2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochim. Biophys. Acta. 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517. PMID 17321610.