SSR1

SSR1
Identifiers
Aliases	SSR1, TRAPA, signal sequence receptor subunit 1
External IDs	OMIM: 600868 MGI: 105082 HomoloGene: 2368 GeneCards: SSR1
Gene location (Human) Chr. Chromosome 6 (human) Band 6p24.3 Start 7,268,306 bp End 7,347,446 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.3 Start 38,150,581 bp End 38,178,193 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis trabecular bone parotid gland tibia germinal epithelium gums seminal vesicula parietal pleura retinal pigment epithelium Top expressed in calvaria molar cumulus cell lacrimal gland dermis abdominal wall condyle fossa vas deferens parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum Biological process IRE1-mediated unfolded protein response cotranslational protein targeting to membrane positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6745 107513 Ensembl ENSG00000124783 ENSMUSG00000021427 UniProt P43307 Q9CY50 RefSeq (mRNA) NM_001292008 NM_003144 NM_025965 NM_001360842 RefSeq (protein) NP_001278937 NP_003135 NP_080241 NP_001347771 Location (UCSC) Chr 6: 7.27 – 7.35 Mb Chr 13: 38.15 – 38.18 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene.

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.

Further reading

• Wei ML, Cresswell P (1992). "HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides". Nature. 356 (6368): 443–6. Bibcode:1992Natur.356..443W. doi:10.1038/356443a0. PMID 1557127. S2CID 4310708.
• Vogel F, Hartmann E, Görlich D, Rapoport TA (1991). "Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane". Eur. J. Cell Biol. 53 (2): 197–202. PMID 1964414.
• Hartmann E, Görlich D, Kostka S, et al. (1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum" (PDF). Eur. J. Biochem. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. hdl:11858/00-001M-0000-0015-3BD2-F. PMID 7916687.
• Hartmann E, Prehn S (1994). "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges". FEBS Lett. 349 (3): 324–6. doi:10.1016/0014-5793(94)00693-8. PMID 8050590. S2CID 42968119.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hirama T, Miller CW, Koeffler HP (1999). "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation". FEBS Lett. 455 (3): 223–7. doi:10.1016/S0014-5793(99)00885-6. PMID 10437777. S2CID 9426244.
• Wang L, Dobberstein B (1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Lett. 457 (3): 316–22. doi:10.1016/S0014-5793(99)01075-3. PMID 10471800. S2CID 22341517.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.