SLITRK2

SLITRK2
Identifiers
Aliases	SLITRK2, CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257
External IDs	OMIM: 300561 MGI: 2679449 HomoloGene: 13054 GeneCards: SLITRK2
Gene location (Human) Chr. X chromosome (human) Band Xq27.3 Start 145,817,829 bp End 145,829,856 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.1 Start 65,692,924 bp End 65,704,999 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus caudate nucleus nucleus accumbens ganglionic eminence middle temporal gyrus amygdala putamen dorsolateral prefrontal cortex Brodmann area 9 prefrontal cortex Top expressed in trigeminal ganglion substantia nigra Region I of hippocampus proper dentate gyrus subiculum primary motor cortex habenula olfactory tubercle hippocampus proper cerebellar vermis More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 84631 245450 Ensembl ENSG00000185985 ENSMUSG00000036790 UniProt Q9H156 Q810C0 RefSeq (mRNA) NM_001144003 NM_001144004 NM_001144005 NM_001144006 NM_001144007 NM_001144008 NM_001144009 NM_001144010 NM_032539 NM_001161431 NM_198863 RefSeq (protein) NP_001137475 NP_001137476 NP_001137477 NP_001137478 NP_001137480 NP_001137481 NP_001137482 NP_115928 NP_001154903 NP_942563 Location (UCSC) Chr X: 145.82 – 145.83 Mb Chr X: 65.69 – 65.7 Mb PubMed search
Wikidata
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SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.