SLC6A14

SLC6A14
Identifiers
Aliases	SLC6A14, BMIQ11, solute carrier family 6 member 14
External IDs	OMIM: 300444 MGI: 1890216 HomoloGene: 38290 GeneCards: SLC6A14
Gene location (Human) Chr. X chromosome (human) Band Xq23 Start 116,436,606 bp End 116,461,458 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A2 Start 21,581,135 bp End 21,608,594 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva lower lobe of lung parotid gland bronchial epithelial cell amniotic fluid minor salivary glands trachea pancreatic epithelial cell sperm visceral pleura Top expressed in left colon conjunctival fornix left lung lobe right lung right lung lobe seminal vesicula olfactory epithelium cornea parotid gland ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function symporter activity amino acid transmembrane transporter activity neurotransmitter:sodium symporter activity transporter activity Cellular component integral component of plasma membrane membrane brush border membrane vesicle extracellular exosome integral component of membrane plasma membrane Biological process neurotransmitter transport amino acid transport cellular amino acid metabolic process response to toxic substance transmembrane transport amino acid transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11254 56774 Ensembl ENSG00000268104 ENSMUSG00000031089 UniProt Q9UN76 Q9JMA9 RefSeq (mRNA) NM_007231 NM_020049 RefSeq (protein) NP_009162 NP_064433 Location (UCSC) Chr X: 116.44 – 116.46 Mb Chr X: 21.58 – 21.61 Mb PubMed search
Wikidata
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Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.

Function

SLC6A14 is a member of the Na⁺- and Cl⁻-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na⁺- and Cl⁻-dependent manner.[supplied by OMIM]

Further reading

• Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jcem.85.9.6797. PMID 10999806.
• Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002. PMID 12388375.
• Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI17491. PMC 281637. PMID 14660752.
• Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes. 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
• Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta. 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.