Protein-coding gene in the species Homo sapiens
Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene .[5] [6]
Interactions SH3GL3 has been shown to interact with Huntingtin [7] SH3KBP1 .[8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000140600 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030638 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics . 41 (3): 427–34. doi :10.1006/geno.1997.4645 . PMID 9169142 . ^ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3" .^ Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates" . Mol. Cell . 2 (4): 427–36. doi :10.1016/S1097-2765(00)80142-2 PMID 9809064 . ^ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. Bibcode :2002Natur.416..187P . doi :10.1038/416187a . PMID 11894096 . S2CID 4389099 .
Further reading
So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ, Sham MH, Wiedemann LM, Chan LC (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia" . Proc. Natl. Acad. Sci. U.S.A . 94 (6): 2563–8. Bibcode :1997PNAS...94.2563S . doi :10.1073/pnas.94.6.2563 PMC 20128 PMID 9122235 . Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain" . Proc. Natl. Acad. Sci. U.S.A . 94 (16): 8569–74. Bibcode :1997PNAS...94.8569R . doi :10.1073/pnas.94.16.8569 PMC 23017 PMID 9238017 . Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates" . Mol. Cell . 2 (4): 427–36. doi :10.1016/S1097-2765(00)80142-2 PMID 9809064 . Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor" . Proc. Natl. Acad. Sci. U.S.A . 96 (22): 12559–64. Bibcode :1999PNAS...9612559T . doi :10.1073/pnas.96.22.12559 PMC 22990 PMID 10535961 . Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmüller U, Schneider-Mergener J, Cesareni G (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity" . J. Biol. Chem . 274 (45): 32001–7. doi :10.1074/jbc.274.45.32001 PMID 10542231 . So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis" . Leukemia . 14 (4): 594–601. doi :10.1038/sj.leu.2401692 PMID 10764144 . So CW, Sham MH, Chew SL, Cheung N, So CK, Chung SK, Caldas C, Wiedemann LM, Chan LC (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins" . Biochem. J . 348 (2): 447–58. doi :10.1042/0264-6021:3480447 . PMC 1221085 PMID 10816441 . Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature . 416 (6877): 187–90. Bibcode :2002Natur.416..187P . doi :10.1038/416187a . PMID 11894096 . S2CID 4389099 . Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization" . J. Biol. Chem . 277 (32): 29108–15. doi :10.1074/jbc.M204019200 PMID 12034747 . Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I (2002). "Ruk is ubiquitinated but not degraded by the proteasome" . Eur. J. Biochem . 269 (14): 3402–8. doi :10.1046/j.1432-1033.2002.03031.x PMID 12135478 . Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases" . J. Biol. Chem . 277 (42): 39666–72. doi :10.1074/jbc.M205535200 PMID 12177062 . Otsuki M, Itoh T, Takenawa T (2003). "Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor" . J. Biol. Chem . 278 (8): 6461–9. doi :10.1074/jbc.M207433200 PMID 12477732 . Yam JW, Jin DY, So CW, Chan LC (2004). "Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein" . Blood . 103 (4): 1445–53. doi :10.1182/blood-2003-07-2452 hdl :10722/48499 PMID 14551139 . Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG , Lehrach H, Wanker EE (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease" . Mol. Cell . 15 (6): 853–65. doi :10.1016/j.molcel.2004.09.016 PMID 15383276 . Trevaskis J, Walder K, Foletta V, Kerr-Bayles L, McMillan J, Cooper A, Lee S, Bolton K, Prior M, Fahey R, Whitecross K, Morton GJ, Schwartz MW, Collier GR (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance" . Endocrinology . 146 (9): 3757–64. doi :10.1210/en.2005-0282 hdl :10536/DRO/DU:30009269 PMID 15919751 . Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways" . Hum. Mol. Genet . 14 (19): 2893–909. doi :10.1093/hmg/ddi321 hdl :11858/00-001M-0000-0010-85BB-5 PMID 16115810 . Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 .
