SEMA6C

SEMA6C
Identifiers
Aliases	SEMA6C, SEMAY, m-SemaY, m-SemaY2, semaphorin 6C, Sema-Y
External IDs	OMIM: 609294 MGI: 1338032 HomoloGene: 7931 GeneCards: SEMA6C
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 151,131,685 bp End 151,146,631 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.1 Start 95,160,457 bp End 95,174,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle ganglionic eminence triceps brachii muscle left ventricle sural nerve vastus lateralis muscle body of tongue gastric mucosa right lobe of liver anterior pituitary Top expressed in triceps brachii muscle temporal muscle sternocleidomastoid muscle spermatocyte vastus lateralis muscle intercostal muscle pyloric antrum tibialis anterior muscle ankle lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function semaphorin receptor binding chemorepellent activity neuropilin binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane cytoplasm cell surface extracellular space Biological process multicellular organism development cell differentiation nervous system development axon guidance negative regulation of axon extension neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10500 20360 Ensembl ENSG00000143434 ENSMUSG00000038777 UniProt Q9H3T2 Q9WTM3 RefSeq (mRNA) NM_001178061 NM_001178062 NM_030913 NM_001272024 NM_011351 RefSeq (protein) NP_001171532 NP_001171533 NP_112175 NP_001258953 NP_035481 Location (UCSC) Chr 1: 151.13 – 151.15 Mb Chr 3: 95.16 – 95.17 Mb PubMed search
Wikidata
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Semaphorin-6C is a protein that in humans is encoded by the SEMA6C gene.

This gene product is a member of the semaphoring family of proteins. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration.

Further reading

• Pasterkamp RJ, Verhaagen J (2001). "Emerging roles for semaphorins in neural regeneration". Brain Res. Brain Res. Rev. 35 (1): 36–54. doi:10.1016/S0165-0173(00)00050-3. PMID 11245885. S2CID 20402160.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.