SEMA4C

SEMA4C
Identifiers
Aliases	SEMA4C, M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDs	OMIM: 604462 MGI: 109252 HomoloGene: 23047 GeneCards: SEMA4C
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.2 Start 96,859,718 bp End 96,870,757 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 B Start 36,587,720 bp End 36,597,430 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb trigeminal ganglion spinal ganglia cerebellar vermis tibial nerve inferior ganglion of vagus nerve sural nerve inferior olivary nucleus endothelial cell pericardium Top expressed in sciatic nerve trigeminal ganglion aortic valve otolith organ utricle ascending aorta ganglionic eminence fossa condyle abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane postsynaptic membrane postsynaptic density plasma membrane synapse synaptic vesicle membrane cell junction cytoplasmic vesicle extracellular space membrane integral component of plasma membrane Biological process cell differentiation cell migration in hindbrain cerebellum development nervous system development multicellular organism development muscle cell differentiation neural tube closure positive regulation of stress-activated MAPK cascade semaphorin-plexin signaling pathway negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54910 20353 Ensembl ENSG00000168758 ENSMUSG00000026121 UniProt Q9C0C4 Q64151 RefSeq (mRNA) NM_017789 NM_001126047 NM_001304329 NM_001304330 RefSeq (protein) NP_060259 NP_001119519 NP_001291258 NP_001291259 Location (UCSC) Chr 2: 96.86 – 96.87 Mb Chr 1: 36.59 – 36.6 Mb PubMed search
Wikidata
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Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.

Interactions

SEMA4C has been shown to interact with DLG4.

Further reading

• Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
• Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
• Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
• Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.