SEDLP
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| TRAPPC2B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | TRAPPC2B, MIP-2A, SEDLP, SEDLP1, TRAPPC2P1, trafficking protein particle complex 2B, trafficking protein particle complex subunit 2B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards: TRAPPC2B | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Trafficking protein particle complex subunit 2 is a protein that in humans is encoded by the TRAPPC2P1 gene.[3]
This gene has been described as a transcribed retropseudogene (or retro-xaptonuon) based on its structure which lacks most of the introns of SEDL and the detection of transcripts from this locus. Most retropseudogenes are thought to not express protein products. A protein product could potentially be encoded by this retropseudogene that would be identical to the protein product of the SEDL gene. However, it remains unclear whether this gene encodes a protein product or is a transcribed retropseudogene.[3]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000256060 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: SEDLP spondyloepiphyseal dysplasia, late, pseudogene".
Further reading
- Sacher M (2003). "Membrane traffic fuses with cartilage development". FEBS Lett. 550 (1–3): 1–4. doi:10.1016/S0014-5793(03)00854-8. PMID 12935876. S2CID 7388750.
- Gécz J, Hillman MA, Gedeon AK, et al. (2001). "Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda". Genomics. 69 (2): 242–51. doi:10.1006/geno.2000.6326. PMID 11031107.
- Ghosh AK, Majumder M, Steele R, et al. (2001). "A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1". Mol. Cell. Biol. 21 (2): 655–62. doi:10.1128/MCB.21.2.655-662.2001. PMC 86643. PMID 11134351.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ghosh AK, Steele R, Ray RB (2003). "Modulation of human luteinizing hormone beta gene transcription by MIP-2A". J. Biol. Chem. 278 (26): 24033–8. doi:10.1074/jbc.M211982200. PMID 12700240.
- Savarirayan R, Thompson E, Gécz J (2004). "Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400)". Eur. J. Hum. Genet. 11 (9): 639–42. doi:10.1038/sj.ejhg.5201025. PMID 12939648.
- Gécz J, Shaw MA, Bellon JR, de Barros Lopes M (2004). "Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not". Gene. 320: 137–44. doi:10.1016/S0378-1119(03)00819-9. PMID 14597397.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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