SAM-VI riboswitch
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SAM-VI is a member of the riboswitch family. It is predominantly found in Bifidobacterium and exhibits some similarities to the SAM-III (Smk box) riboswitch class, but lacks most of the highly conserved nucleotides of SAM-III class. SAM-VI aptamers bind the cofactor S-adenosylmethinine SAM (a key metabolite in sulphur metabolism) and discriminate strongly against S-adenosylhomocysteine SAH. The class was discovered by further analysis of Bifido-meK motif RNAs.[1]
See also
References
- ^ Gayan, Mirihana Arachchilage; Sherlock, Madeline E.; Weinberg, Zasha; Breaker, Ronald R. (2018-02-12). "SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches". RNA Biology. 15 (3): 371–378. doi:10.1080/15476286.2017.1399232. ISSN 1555-8584. PMC 5927728. PMID 29106323.