Rhamnulose-1-phosphate aldolase
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| rhamnulose-1-phosphate aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.2.19 | ||||||||
| CAS no. | 9054-58-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme rhamnulose-1-phosphate aldolase (EC 4.1.2.19) catalyzes the chemical reaction
- L-rhamnulose 1-phosphate glycerone phosphate[1] + (S)-lactaldehyde
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-rhamnulose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include rhamnulose phosphate aldolase, L-rhamnulose 1-phosphate aldolase, L-rhamnulose-phosphate aldolase, and L-rhamnulose-1-phosphate lactaldehyde-lyase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1GT7 and 1OJR.
References
- ^ Glycerone phosphate is often known as dihydroxyacetone phosphate.
- Chiu TH, Feingold DS (1969). "L-rhamnulose 1-phosphate aldolase from Escherichia coli Crystallization and properties". Biochemistry. 8 (1): 98–108. doi:10.1021/bi00829a015. PMID 4975916.
- Sawada H; Takagi Y (1964). "The metabolism of L-rhamnose in Escherichia coli. 3 L-Rhamulose-phosphate aldolase". Biochim. Biophys. Acta. 92: 26–32. doi:10.1016/0926-6569(64)90265-2. PMID 14243785.
