|Indigo naturalis||Traditional Chinese medicine|
|Other names||RIF oral arsenic formulation, Compound Huangdai|
|Defined daily dose||not established|
Realgar/Indigo naturalis (RIF), also known as Compound Huangdai, is a medication used to treat acute promyelocytic leukemia. Effectiveness appears similar to arsenic trioxide. It is generally used together with all-trans-retinoic acid (ATRA). It is taken by mouth.
Side effects may include abdominal pain and rash. It is made up of a combination of realgar (tetra-arsenic tetra-sulfide), Indigo naturalis, root of Salvia miltiorrhiza, and root of Pseudostellaria heterophylla. It works by breaking down the cancer protein retinoic acid receptor alpha.
Realgar-Indigo naturalis was developed in the 1980s and approved for medical use in China in 2009. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. It is made in China and was originally a herbal remedy. It is not very expensive. It is not approved in either the United States or Europe as of 2019.
- "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 10 September 2020.
- "Proposal for the inclusion of arsenic therapies in the WHO Model list of ESSENTIAL MEDICINES for the treatment of acute promyelocytic leukemia" (PDF). WHO. Retrieved 15 November 2019.
- World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
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