RUFY1

RUFY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YQM, 2YW8
Identifiers
Aliases	RUFY1, RABIP4, ZFYVE12, RUN and FYVE domain containing 1
External IDs	OMIM: 610327 MGI: 2429762 HomoloGene: 23522 GeneCards: RUFY1
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.3 Start 179,550,554 bp End 179,610,012 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B1.3 Start 50,280,113 bp End 50,321,952 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon sural nerve corpus callosum blood right uterine tube gastric mucosa right lung spleen skin of abdomen Top expressed in proximal tubule retinal pigment epithelium secondary oocyte lip seminal vesicula interventricular septum superior frontal gyrus temporal muscle triceps brachii muscle adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding lipid binding SH3 domain binding SH2 domain binding Cellular component intracellular membrane-bounded organelle membrane cytoplasm cytosol nuclear speck early endosome membrane endosome nucleus Biological process protein transport endocytosis phosphatidylinositol biosynthetic process regulation of endocytosis small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80230 216724 Ensembl ENSG00000284260 ENSG00000176783 ENSMUSG00000020375 UniProt Q96T51 Q8BIJ7 RefSeq (mRNA) NM_001040451 NM_001040452 NM_025158 NM_172557 RefSeq (protein) NP_001035541 NP_001035542 NP_079434 NP_766145 Location (UCSC) Chr 5: 179.55 – 179.61 Mb Chr 11: 50.28 – 50.32 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene. It is named after the RUN and FYVE domains it contains.

Interactions

RUFY1 has been shown to interact with BMX.

Further reading

• Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand-Brustel Y (2001). "A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1637–42. doi:10.1073/pnas.031586998. PMC 29309. PMID 11172003.
• Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ (2004). "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes". Mol. Biol. Cell. 15 (2): 611–24. doi:10.1091/mbc.E03-05-0343. PMC 329268. PMID 14617813.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.