Protein-coding gene in the species Homo sapiens
Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene .[5] [6]
Interactions RRAS has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000126458 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038387 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lowe DG, Capon DJ, Delwart E, Sakaguchi AY, Naylor SL, Goeddel DV (February 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell . 48 (1): 137–46. doi :10.1016/0092-8674(87)90364-3 . PMID 3098437 . S2CID 22622027 . ^ "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog" .^ Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics . 81 (2): 112–25. doi :10.1016/s0888-7543(02)00008-3 . PMID 12620389 . ^ Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (July 2000). "Isoform-specific localization of A-RAF in mitochondria" . Mol. Cell. Biol . 20 (13): 4870–8. doi :10.1128/mcb.20.13.4870-4878.2000 . PMC 85938 PMID 10848612 . ^ Fernandez-Sarabia MJ, Bischoff JR (November 1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature . 366 (6452): 274–5. Bibcode :1993Natur.366..274F . doi :10.1038/366274a0 . PMID 8232588 . S2CID 4312803 . ^ Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (February 2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras" . J. Biol. Chem . 275 (7): 5222–7. doi :10.1074/jbc.275.7.5222 PMID 10671570 . ^ Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap" . Proc. Natl. Acad. Sci. U.S.A . 91 (26): 12609–13. Bibcode :1994PNAS...9112609S . doi :10.1073/pnas.91.26.12609 PMC 45488 PMID 7809086 . ^ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (February 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1" . Oncogene . 21 (9): 1381–90. doi :10.1038/sj.onc.1205192 PMID 11857081 .
Further reading
Carboni JM, Yan N, Cox AD, Bustelo X, Graham SM, Lynch MJ, Weinmann R, Seizinger BR, Der CJ, Barbacid M (1995). "Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation". Oncogene . 10 (10): 1905–13. PMID 7761092 . Spaargaren M, Bischoff JR (1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap" . Proc. Natl. Acad. Sci. U.S.A . 91 (26): 12609–13. Bibcode :1994PNAS...9112609S . doi :10.1073/pnas.91.26.12609 PMC 45488 PMID 7809086 . Fernandez-Sarabia MJ, Bischoff JR (1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature . 366 (6452): 274–5. Bibcode :1993Natur.366..274F . doi :10.1038/366274a0 . PMID 8232588 . S2CID 4312803 . Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily" . J. Biol. Chem . 274 (19): 13556–62. doi :10.1074/jbc.274.19.13556 PMID 10224125 . Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, Philips MR (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi" . Cell . 98 (1): 69–80. doi :10.1016/S0092-8674(00)80607-8 PMID 10412982 . S2CID 1018802 . Zou JX, Wang B, Kalo MS, Zisch AH, Pasquale EB, Ruoslahti E (1999). "An Eph receptor regulates integrin activity through R-Ras" . Proc. Natl. Acad. Sci. U.S.A . 96 (24): 13813–8. Bibcode :1999PNAS...9613813Z . doi :10.1073/pnas.96.24.13813 PMC 24147 PMID 10570155 . Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras" . J. Biol. Chem . 275 (7): 5222–7. doi :10.1074/jbc.275.7.5222 PMID 10671570 . Suzuki J, Kaziro Y, Koide H (2000). "Positive regulation of skeletal myogenesis by R-Ras" . Oncogene . 19 (9): 1138–46. doi :10.1038/sj.onc.1203402 PMID 10713701 . Ohba Y, Mochizuki N, Yamashita S, Chan AM, Schrader JW, Hattori S, Nagashima K, Matsuda M (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3" . J. Biol. Chem . 275 (26): 20020–6. doi :10.1074/jbc.M000981200 PMID 10777492 . Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (2000). "Isoform-specific localization of A-RAF in mitochondria" . Mol. Cell. Biol . 20 (13): 4870–8. doi :10.1128/MCB.20.13.4870-4878.2000 . PMC 85938 PMID 10848612 . Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE (2000). "The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function" . Oncogene . 19 (43): 4961–9. doi :10.1038/sj.onc.1203876 PMID 11042683 . Tian X, Feig LA (2001). "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors" . J. Biol. Chem . 276 (50): 47248–56. doi :10.1074/jbc.M107407200 PMID 11560935 . Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1" . Oncogene . 21 (9): 1381–90. doi :10.1038/sj.onc.1205192 PMID 11857081 . Yu Y, Feig LA (2002). "Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells" . Oncogene . 21 (49): 7557–68. doi :10.1038/sj.onc.1205961 PMID 12386818 . Kwong L, Wozniak MA, Collins AS, Wilson SD, Keely PJ (2003). "R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins" . Mol. Cell. Biol . 23 (3): 933–49. doi :10.1128/MCB.23.3.933-949.2003 . PMC 140691 PMID 12529399 . Rincón-Arano H, Rosales R, Mora N, Rodriguez-Castañeda A, Rosales C (2003). "R-Ras promotes tumor growth of cervical epithelial cells" . Cancer . 97 (3): 575–85. doi :10.1002/cncr.11093 PMID 12548599 . S2CID 22504390 . Furuhjelm J, Peränen J (2003). "The C-terminal end of R-Ras contains a focal adhesion targeting signal" . J. Cell Sci . 116 (Pt 18): 3729–38. doi :10.1242/jcs.00689 PMID 12890755 . Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization" . J. Biol. Chem . 279 (21): 22353–61. doi :10.1074/jbc.M312867200 PMID 15031288 .
