Protein-coding gene in the species Homo sapiens
RDH11 Identifiers Aliases RDH11 External IDs OMIM : 607849 MGI : 102581 HomoloGene : 100724 GeneCards : RDH11 Wikidata
Retinol dehydrogenase 11 is an enzyme that in humans is encoded by the RDH11 gene .[4] [5] [6] [7]
RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases , is expressed at high levels in prostate epithelium, and its expression is regulated by androgens .[supplied by OMIM][7]
Clinical significance Mutations in RDH11 are associated to retinitis pigmentosa .[8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000072042 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Haeseleer F, Jang GF, Imanishi Y, et al. (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina" . J Biol Chem . 277 (47): 45537–46. doi :10.1074/jbc.M208882200 PMC 1435693 PMID 12226107 . ^ Hara T, Harada N, Mitsui H, et al. (Aug 1994). "Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line" . Blood . 84 (1): 189–99. doi :10.1182/blood.V84.1.189.189 PMID 8018917 . ^ ^ a b "Entrez Gene: RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)" .^ Xie YA, Lee W, Cai C, et al. (2014). "New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11" . Human Molecular Genetics . 23 (21): 5774–5780. doi :10.1093/hmg/ddu291 . PMC 4189905 PMID 24916380 .
Further reading
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics" . Genome Res . 10 (5): 703–13. doi :10.1101/gr.10.5.703 . PMC 310876 PMID 10810093 . Lin B, White JT, Ferguson C, et al. (2001). "Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium". Cancer Res . 61 (4): 1611–8. PMID 11245473 . Kedishvili NY, Chumakova OV, Chetyrkin SV, et al. (2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)" . J. Biol. Chem . 277 (32): 28909–15. doi :10.1074/jbc.M202588200 PMID 12036956 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Li K, Wang L, Cheng J, et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus" . World J. Gastroenterol . 9 (2): 300–3. doi :10.3748/wjg.v9.i2.300 PMC 4611333 PMID 12532453 . Belyaeva OV, Stetsenko AV, Nelson P, et al. (2004). "Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines". Biochemistry . 42 (50): 14838–45. doi :10.1021/bi035288u . PMID 14674758 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26. doi :10.1093/dnares/12.2.117 PMID 16303743 . Kasus-Jacobi A, Birch DG, Anderson RE (2006). "Photoreceptor Retinol Dehydrogenases". Retinal Degenerative Diseases 505–11 . doi :10.1007/0-387-32442-9_70 . ISBN 978-0-387-28464-4 PMID 17249616 . Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes" . BMC Genomics . 8 : 42. doi :10.1186/1471-2164-8-42 PMC 1802077 PMID 17286855 .
