Quinfamide
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Clinical data | |
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Routes of administration | Oral |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.057.690 |
Chemical and physical data | |
Formula | C16H13Cl2NO4 |
Molar mass | 354.18 g·mol−1 |
3D model (JSmol) | |
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Quinfamide is a drug that has anti-parasitic properties.[1]
Synthesis
Quinfamide is one of a relatively small family of antiamoebic compounds containing a dichloroacetamide function.[citation needed]
The synthesis begins by amidation of 6-hydroxytetrahydroquinoline with dichloroacetyl chloride. The sequence is completed by acylation with 2-furoyl chloride.
References
- ^ Davila-Gutierrez CE, Vasquez C, Trujillo-Hernandez B, Huerta M (March 2002). "Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children". The American Journal of Tropical Medicine and Hygiene. 66 (3): 251–4. doi:10.4269/ajtmh.2002.66.251. PMID 12139216.
- ^ US 3997542, Bailey, Denis Mahlon, "1-(Halogenated-acetyl)-1,2,3,4-tetrahydro-6-quinolinols and esters thereof", published 1976-12-14, assigned to Sterling Drug Inc.
- ^ Bailey DM, Mount EM, Siggins J, Carlson JA, Yarinsky A, Slighter RG (May 1979). "1-(Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinol esters. New potent antiamebic agents". Journal of Medicinal Chemistry. 22 (5): 599–601. doi:10.1021/jm00191a031. PMID 458814.
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- Antiprotozoal agents
- Tetrahydroquinolines
- Amides
- 2-Furyl compounds
- Phenol esters