Protoporphyrinogen IX dehydrogenase (menaquinone)

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Protoporphyrinogen IX dehydrogenase (menaquinone)
Identifiers
EC no.1.3.5.3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

Protoporphyrinogen IX dehydrogenase (menaquinone) (EC 1.3.5.3, HemG) is an enzyme with systematic name protoporphyrinogen IX:menaquinone oxidoreductase.[1] This enzyme catalyses the following chemical reaction

protoporphyrinogen IX + 3 menaquinone protoporphyrin IX + 3 menaquinol

This enzyme enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments.

References

  1. ^ Boynton TO, Daugherty LE, Dailey TA, Dailey HA (July 2009). "Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity". Biochemistry. 48 (29): 6705–11. doi:10.1021/bi900850y. PMC 2749469. PMID 19583219.

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