PTRF

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CAVIN1
Identifiers
AliasesCAVIN1, CAVIN, CGL4, cavin-1, FKSG13, PTRF, polymerase I and transcript release factor, caveolae associated protein 1
External IDsOMIM: 603198 MGI: 1277968 HomoloGene: 7499 GeneCards: CAVIN1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012232

NM_008986
NM_001359105
NM_027160

RefSeq (protein)

NP_036364

NP_033012
NP_001346034

Location (UCSC)Chr 17: 42.4 – 42.42 MbChr 11: 100.85 – 100.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a protein which in humans is encoded by the PTRF gene.[5][6]

Function

PTRF (Cavin1) has been shown to be crucial for caveola formation and function.[7] Deformation caveolae promotes the translocation of cavin-1 from caveolae to the nucleus[8]

Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.[9][10]

PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.[11]

Interactions

PTRF (Cavin1) forms trimers with Cavin2 and Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as EHD2 and caveolins.[12]

PTRF has been shown to interact with ZNF148.[13]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177469 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004044 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PTRF polymerase I and transcript release factor".
  6. ^ "CAVIN1 Symbol Report | HUGO Gene Nomenclature Committee". www.genenames.org. Retrieved 2017-05-30.
  7. ^ Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, et al. (January 2008). "PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function". Cell. 132 (1): 113–124. doi:10.1016/j.cell.2007.11.042. PMC 2265257. PMID 18191225.
  8. ^ Qifti A, Balaji S, Scarlata S (June 2022). "Deformation of caveolae impacts global transcription and translation processes through relocalization of cavin-1". The Journal of Biological Chemistry. 298 (6): 102005. doi:10.1016/j.jbc.2022.102005. PMC 9168624. PMID 35513070.
  9. ^ Mason SW, Sander EE, Grummt I (January 1997). "Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I". The EMBO Journal. 16 (1): 163–172. doi:10.1093/emboj/16.1.163. PMC 1169623. PMID 9009277.
  10. ^ Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (May 1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". The EMBO Journal. 17 (10): 2855–2864. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
  11. ^ Aboulaich N, Vainonen JP, Strålfors P, Vener AV (October 2004). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". The Biochemical Journal. 383 (Pt 2): 237–248. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
  12. ^ Kovtun O, Tillu VA, Ariotti N, Parton RG, Collins BM (April 2015). "Cavin family proteins and the assembly of caveolae". Journal of Cell Science. 128 (7): 1269–1278. doi:10.1242/jcs.167866. PMC 4379724. PMID 25829513.
  13. ^ Hasegawa T, Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K (April 2000). "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". The Biochemical Journal. 347 Pt 1 (Pt 1): 55–59. doi:10.1042/0264-6021:3470055. PMC 1220930. PMID 10727401.

Further reading