PRMT8
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Protein arginine methyltransferase 8 is a protein that in humans is encoded by the PRMT8 gene.[1] Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction and protein compartmentalization.[1] PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein.[2]
References
Further reading
- Pahlich, S.; Zakaryan, R. P.; Gehring, H. (2008). "Identification of proteins interacting with protein arginine methyltransferase 8: The Ewing sarcoma (EWS) protein binds independent of its methylation state". Proteins: Structure, Function, and Bioinformatics. 72 (4): 1125–1137. doi:10.1002/prot.22004. PMID 18320585. S2CID 206402713.
- Sayegh, J.; Webb, K.; Cheng, D.; Bedford, M. T.; Clarke, S. G. (2007). "Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain". Journal of Biological Chemistry. 282 (50): 36444–36453. doi:10.1074/jbc.M704650200. PMID 17925405.
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