PRKX
Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene. [5]
Function
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.
Nomenclature
Mouse ortholog for this gene, Prkx, is also known as Pkare.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183943 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035725 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Protein kinase, X-linked". Retrieved 2017-05-19.
- ^ "Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]". National Center for Biotechnology Information.
Further reading
- Li X, Li HP, Amsler K, Hyink D, Wilson PD, Burrow CR (2002). "PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9260–5. Bibcode:2002PNAS...99.9260L. doi:10.1073/pnas.132051799. PMC 123128. PMID 12082174.
- Li X, Burrow CR, Polgar K, Hyink DP, Gusella GL, Wilson PD (2008). "Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency" (PDF). Biochim. Biophys. Acta. 1782 (1): 1–9. doi:10.1016/j.bbadis.2007.09.003. PMID 17980165. S2CID 23224610.
- Li X, Iomini C, Hyink D, Wilson PD (2011). "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation". Dev. Biol. 356 (2): 475–85. doi:10.1016/j.ydbio.2011.05.673. PMID 21684272.
- Lin Y, Li W (2011). "MBD 4--a potential substrate for protein kinase X". Acta Biochim. Biophys. Sin. (Shanghai). 43 (11): 916–7. doi:10.1093/abbs/gmr086. PMID 21971312.
- Bender C, Ullrich A (2012). "PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines". Int. J. Cancer. 131 (2): E45–55. doi:10.1002/ijc.26486. PMID 22020623. S2CID 27590197.
- Huang S, Li Q, Alberts I, Li X (2016). "PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development". J. Cell. Biochem. 117 (3): 566–73. doi:10.1002/jcb.25304. PMID 26252946. S2CID 45734891.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.