PRB3

PRB3
Identifiers
Aliases	PRB3, G1, PRG, proline-rich protein BstNI subfamily 3, proline rich protein BstNI subfamily 3
External IDs	OMIM: 168840 HomoloGene: 133260 GeneCards: PRB3
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 11,265,914 bp End 11,269,707 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus bone marrow bone marrow cells sural nerve salivary gland rectum skin of abdomen urinary bladder mucosa of large intestine minor salivary glands n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 5544 n/a Ensembl ENSG00000197870 ENSG00000275624 n/a UniProt Q04118 n/a RefSeq (mRNA) NM_006249 NM_001394862 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 11.27 – 11.27 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Basic salivary proline-rich protein 3 is a protein that in humans is encoded by the PRB3 gene.

The protein encoded by this gene is a proline-rich salivary protein. It is a major constituent of parotid saliva. This protein is proposed to act as a bacterial receptor. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region.

Further reading

• Azen EA, Maeda N (1988). "Molecular Genetics of Human Salivary Proteins and Their Polymorphisms". Advances in Human Genetics 1. Vol. 17. pp. 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850. {{cite book}}: |journal= ignored (help)
• Azen EA, Minaguchi K, Latreille P, Kim HS (1990). "Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew". Am. J. Hum. Genet. 47 (4): 686–97. PMC 1683781. PMID 2171329.
• Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Azen E, Prakobphol A, Fisher SJ (1993). "PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro". Infect. Immun. 61 (10): 4434–9. doi:10.1128/IAI.61.10.4434-4439.1993. PMC 281176. PMID 8406834.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.