Protein-coding gene in the species Homo sapiens
Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene .[5] [6] [7]
Interactions PPP1R2 has been shown to interact with LMTK2 [8] PPP1R9B .[9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000184203 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047714 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Permana PA, Mott DM (April 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians" . Genomics . 41 (1): 110–4. doi :10.1006/geno.1997.4649 . PMID 9126490 . ^ Helps NR, Street AJ, Elledge SJ, Cohen PT (February 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli" . FEBS Letters . 340 (1–2): 93–8. doi :10.1016/0014-5793(94)80179-7 PMID 8119416 . S2CID 10674654 . ^ "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2" .^ Wang H, Brautigan DL (December 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2" . The Journal of Biological Chemistry . 277 (51): 49605–12. doi :10.1074/jbc.M209335200 PMID 12393858 . ^ Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton" . The Journal of Biological Chemistry . 277 (48): 46535–43. doi :10.1074/jbc.M206960200 PMID 12270929 .
Further reading
Sanséau P, Jackson A, Alderton RP, Beck S, Senger G, Sheer D, et al. (August 1994). "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences". Mammalian Genome . 5 (8): 490–6. doi :10.1007/BF00369318 . PMID 7949733 . S2CID 11381670 . Park IK, Roach P, Bondor J, Fox SP, DePaoli-Roach AA (January 1994). "Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2" . The Journal of Biological Chemistry . 269 (2): 944–54. doi :10.1016/S0021-9258(17)42203-4 PMID 8288648 . Kakinoki Y, Somers J, Brautigan DL (December 1997). "Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle" . The Journal of Biological Chemistry . 272 (51): 32308–14. doi :10.1074/jbc.272.51.32308 PMID 9405437 . Yang J, Hurley TD, DePaoli-Roach AA (July 2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif" . The Journal of Biological Chemistry . 275 (30): 22635–44. doi :10.1074/jbc.M003082200 PMID 10807923 . Agarwal-Mawal A, Paudel HK (June 2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2" . The Journal of Biological Chemistry . 276 (26): 23712–8. doi :10.1074/jbc.M010002200 PMID 11320080 . Eto M, Elliott E, Prickett TD, Brautigan DL (November 2002). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation" . The Journal of Biological Chemistry . 277 (46): 44013–20. doi :10.1074/jbc.M208035200 PMID 12221103 . Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton" . The Journal of Biological Chemistry . 277 (48): 46535–43. doi :10.1074/jbc.M206960200 PMID 12270929 . Wang H, Brautigan DL (December 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2" . The Journal of Biological Chemistry . 277 (51): 49605–12. doi :10.1074/jbc.M209335200 PMID 12393858 . Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology . 21 (5): 566–9. doi :10.1038/nbt810 . PMID 12665801 . S2CID 23783563 . Leach C, Shenolikar S, Brautigan DL (July 2003). "Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis" . The Journal of Biological Chemistry . 278 (28): 26015–20. doi :10.1074/jbc.M300782200 PMID 12697755 . Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry . 133 (2): 165–71. doi :10.1093/jb/mvg020 . PMID 12761178 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Yamada M, Ikeda Y, Yano M, Yoshimura K, Nishino S, Aoyama H, et al. (June 2006). "Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy" . FASEB Journal . 20 (8): 1197–9. doi :10.1096/fj.05-5299fje PMID 16627625 . S2CID 911020 . King TD, Gandy JC, Bijur GN (November 2006). "The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels" . Experimental Cell Research . 312 (18): 3693–700. doi :10.1016/j.yexcr.2006.08.010 . PMC 1885546 PMID 16987514 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
