PPIP5K2

PPIP5K2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB
Identifiers
Aliases	PPIP5K2, HISPPD1, IP7K2, VIP2, CFAP160, diphosphoinositol pentakisphosphate kinase 2, DFNB100
External IDs	OMIM: 611648 MGI: 2142810 HomoloGene: 49409 GeneCards: PPIP5K2
Gene location (Human) Chr. Chromosome 5 (human) Band 5q21.1 Start 103,120,149 bp End 103,212,799 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 97,706,048 bp End 97,770,411 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence sural nerve bone marrow cells tibia monocyte rectum body of pancreas left coronary artery germinal epithelium Top expressed in hand superior cervical ganglion interventricular septum secondary oocyte myocardium of ventricle trigeminal ganglion jejunum lens spermatocyte ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function inositol hexakisphosphate 5-kinase activity transferase activity inositol hexakisphosphate 1-kinase activity nucleotide binding diphosphoinositol-pentakisphosphate kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol hexakisphosphate 3-kinase activity kinase activity inositol hexakisphosphate kinase activity ATP binding inositol heptakisphosphate kinase activity 5-diphosphoinositol pentakisphosphate 3-kinase activity Cellular component cytoplasm cytosol Biological process inositol phosphate metabolic process phosphorylation inositol phosphate biosynthetic process inositol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23262 227399 Ensembl ENSG00000145725 ENSMUSG00000040648 UniProt O43314 Q6ZQB6 RefSeq (mRNA) NM_001276277 NM_001281471 NM_015216 NM_001345871 NM_001345872 NM_001345873 NM_001345874 NM_001345875 NM_001345876 NM_001345877 NM_001345878 NM_173760 RefSeq (protein) NP_001263206 NP_001268400 NP_001332800 NP_001332801 NP_001332802 NP_001332803 NP_001332804 NP_001332805 NP_001332806 NP_001332807 NP_056031 NP_776121 NP_001392387 NP_001392388 NP_001392389 NP_001392390 NP_001392391 NP_001392392 NP_001392393 NP_001392394 NP_001392395 NP_001392396 NP_001392397 NP_001392398 NP_001392399 NP_001392400 NP_001392401 NP_001392402 Location (UCSC) Chr 5: 103.12 – 103.21 Mb Chr 1: 97.71 – 97.77 Mb PubMed search
Wikidata
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Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene.

Function

Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.

HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Wang H, Falck JR, Hall TM, Shears SB (2011). "Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding". Nat. Chem. Biol. 8 (1): 111–6. doi:10.1038/nchembio.733. PMC 3923263. PMID 22119861.
• Weaver JD, Wang H, Shears SB (2013). "The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment". Biosci. Rep. 33 (2): e00022. doi:10.1042/BSR20120115. PMC 3564036. PMID 23240582.
• Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB (2015). "Identification of a functional nuclear translocation sequence in hPPIP5K2". BMC Cell Biol. 16: 17. doi:10.1186/s12860-015-0063-7. PMC 4472268. PMID 26084399.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.