Protein-coding gene in the species Homo sapiens
Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2 gene in humans.[5] [6]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[6] [7] [8] [9]
Interactions In the nucleus, POLDIP2 has been shown to interact with PCNA ,[5] [10] AAA + protease CLPXP [9] [11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000004142 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001100 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (March 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen" . The Journal of Biological Chemistry . 278 (12): 10041–7. doi :10.1074/jbc.M208694200 PMID 12522211 . ^ a b "Entrez Gene: POLDIP2 polymerase (DNA-directed), delta interacting protein 2" .^ Wong A, Zhang S, Mordue D, Wu JM, Zhang Z, Darzynkiewicz Z, et al. (October 2013). "PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2" . Cell Cycle . 12 (19): 3184–93. doi :10.4161/cc.26221 . PMC 3865014 PMID 23989611 . ^ Xie B, Li H, Wang Q, Xie S, Rahmeh A, Dai W, Lee MY (June 2005). "Further characterization of human DNA polymerase delta interacting protein 38" . The Journal of Biological Chemistry . 280 (23): 22375–84. doi :10.1074/jbc.M414597200 PMID 15811854 . ^ a b Strack PR, Brodie EJ, Zhan H, Schuenemann VJ, Valente LJ, Saiyed T, et al. (November 2020). "Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP" . Communications Biology . 3 (1): 646. doi :10.1038/s42003-020-01358-6 . PMC 7647994 PMID 33159171 . ^ Cheng X, Kanki T, Fukuoh A, Ohgaki K, Takeya R, Aoki Y, et al. (December 2005). "PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid". Journal of Biochemistry . 138 (6): 673–8. doi :10.1093/jb/mvi169 . PMID 16428295 . ^ Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, et al. (February 2018). "Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer" . Proceedings of the National Academy of Sciences of the United States of America . 115 (8): 1789–1794. Bibcode :2018PNAS..115.1789P . doi :10.1073/pnas.1720693115 PMC 5828627 PMID 29434038 .
Further reading
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Research . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 PMID 11042152 . Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Reports . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Research . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Xie B, Li H, Wang Q, Xie S, Rahmeh A, Dai W, Lee MY (June 2005). "Further characterization of human DNA polymerase delta interacting protein 38" . The Journal of Biological Chemistry . 280 (23): 22375–84. doi :10.1074/jbc.M414597200 PMID 15811854 . Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006" . Nucleic Acids Research . 34 (Database issue): D415-8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Klaile E, Müller MM, Kannicht C, Otto W, Singer BB, Reutter W, et al. (September 2007). "The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38" . The Journal of Biological Chemistry . 282 (36): 26629–40. doi :10.1074/jbc.M701807200 PMID 17623671 .
