PFDN5

PFDN5
Identifiers
Aliases	PFDN5, MM-1, MM1, PFD5, prefoldin subunit 5
External IDs	OMIM: 604899 MGI: 1928753 HomoloGene: 1972 GeneCards: PFDN5
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 53,295,291 bp End 53,299,452 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F2|15 57.48 cM Start 102,234,551 bp End 102,240,308 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary canal of the cervix hypothalamus nucleus accumbens amygdala substantia nigra right uterine tube Achilles tendon monocyte Top expressed in arcuate nucleus endocardial cushion mammillary body paraventricular nucleus of hypothalamus globus pallidus medial ganglionic eminence lateral hypothalamus seminal vesicula median eminence ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein binding transcription corepressor activity Cellular component cytoplasm nucleus prefoldin complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated retina development in camera-type eye negative regulation of canonical Wnt signaling pathway protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5204 56612 Ensembl ENSG00000123349 ENSMUSG00000001289 UniProt Q99471 Q9WU28 RefSeq (mRNA) NM_145897 NM_002624 NM_145896 NM_020031 NM_027044 RefSeq (protein) NP_002615 NP_665904 NP_081320 Location (UCSC) Chr 12: 53.3 – 53.3 Mb Chr 15: 102.23 – 102.24 Mb PubMed search
Wikidata
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Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.

Interactions

PFDN5 has been shown to interact with Myc.

Further reading

• Hansen WJ, Cowan NJ, Welch WJ (April 1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins". The Journal of Cell Biology. 145 (2): 265–77. doi:10.1083/jcb.145.2.265. PMC 2133115. PMID 10209023.
• Cowan NJ, Lewis SA (November 1999). "A chaperone with a hydrophilic surface". Nature Structural Biology. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082. S2CID 22081346.
• Rommelaere H, De Neve M, Neirynck K, Peelaers D, Waterschoot D, Goethals M, Fraeyman N, Vandekerckhove J, Ampe C (November 2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". The Journal of Biological Chemistry. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601.
• Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H (November 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". The Journal of Biological Chemistry. 276 (48): 45137–44. doi:10.1074/jbc.M106127200. PMID 11567024.
• Watanabe K, Ozaki T, Nakagawa T, Miyazaki K, Takahashi M, Hosoda M, Hayashi S, Todo S, Nakagawara A (April 2002). "Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function". The Journal of Biological Chemistry. 277 (17): 15113–23. doi:10.1074/jbc.M111281200. PMID 11844794.
• Simons CT, Staes A, Rommelaere H, Ampe C, Lewis SA, Cowan NJ (February 2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". The Journal of Biological Chemistry. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (October 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Hagio Y, Kimura Y, Taira T, Fujioka Y, Iguchi-Ariga SM, Ariga H (January 2006). "Distinct localizations and repression activities of MM-1 isoforms toward c-Myc". Journal of Cellular Biochemistry. 97 (1): 145–55. doi:10.1002/jcb.20619. PMID 16173081. S2CID 6803370.